The prognostic value of P53 index in predicting the recurrence of early low-risk endometrial cancer

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dc.contributor.authorÇakır, İlker
dc.contributor.authorGülseren, Varol
dc.contributor.authorAköz, Gamze
dc.contributor.authorŞahin, Zekiye
dc.contributor.authorSever, Barış
dc.contributor.authorEmiralioğlu Çakır, Zübeyde
dc.contributor.authorSancı, Muzaffer
dc.contributor.authorKuru, Oğuzhan
dc.contributor.authorÖzdemir, İsa Aykut
dc.contributor.authorGüngördük, Kemal
dc.date.accessioned2024-01-31T11:45:47Z
dc.date.available2024-01-31T11:45:47Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.description.abstractAim: We aimed to clarify the clinical value of P53 index in patients with early low-risk endometrial cancer (EC) and find an optimal cut-off value of P53 index for predicting the recurrence of these patients.Methods: The clinicopathological data of 157 patients with early low-risk EC (stage 1A with grade 1 or 2 endometrioid EC) were analyzed. The optimal cut-off value of the P53 index was calculated by the receiver operating characteristic curve analysis and Youden index. Cox regression model was used to evaluate the independent prognostic predictors of recurrence of EC. Then all patients were divided into two groups according to the optimal cut-off value of the P53 index. Differences of the clinicopathological parameters between the two groups were compared.Results: Multivariate analysis showed age PR (p = 0.020) and P53 (p = 0.001) were independent prognostic factors for the recurrence of EC. The value of P53 index was found to be the optimal cut-off point of 17.5% in estimating the recurrence of EC. The 5-year recurrence-free survival rates of patients in the low P53 index group (<17.5%) and the high P53 index group (=17.5%) were 94.6% and 65.4% (p < 0.001).Conclusion: It has been revealed that the P53 index is a prognostic factor for recurrence in early low-risk EC. The optimal cut-off value of P53 index may contribute to the postoperative individualized treatment options for early low-risk EC patients.
dc.identifier.citationÇakır, İ., Gülseren, V., Aköz, G., Şahin, Z., Sever, B., Emiralioğlu Çakır, Z. ... Güngördük, K. (2023). The prognostic value of P53 index in predicting the recurrence of early low-risk endometrial cancer. Journal of Obstetrics and Gynaecology Research, 49(10), 2487-2493. https://dx.doi.org/10.1111/jog.15754
dc.identifier.doi10.1111/jog.15754
dc.identifier.endpage2493
dc.identifier.issn1341-8076
dc.identifier.issn1447-0756
dc.identifier.issue10
dc.identifier.pmid37497887
dc.identifier.scopus2-s2.0-85165904054
dc.identifier.scopusqualityQ2
dc.identifier.startpage2487
dc.identifier.urihttps://dx.doi.org/10.1111/jog.15754
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12227
dc.identifier.volume49
dc.identifier.wos001037860300001en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzdemir, İsa Aykut
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Obstetrics and Gynaecology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectDisease-Free Survival
dc.subjectEndometrial Cancer
dc.subjectPrognosis
dc.subjectRecurrence
dc.subjectTumor Marker
dc.titleThe prognostic value of P53 index in predicting the recurrence of early low-risk endometrial cancer
dc.typeArticle

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