Combination therapy with selective serotonin reuptake inhibitors and phosphodiesterase-5 inhibitors in the treatment of premature ejaculation

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dc.authorid0000-0001-5254-2563
dc.contributor.authorPolat, Emre Can
dc.contributor.authorÖzbek, Emin
dc.contributor.authorÖtünçtemur, Alper
dc.contributor.authorÖzcan, Levent
dc.contributor.authorŞimşek, Abdülmuttalip
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:35:32Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:35:32Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.description.abstractWe aimed to evaluate the effectiveness of paroxetine and tadalafil combination in the treatment of premature ejaculation (PE). A total of 150 primary (lifelong)PE patients were randomly distributed into three groups of 50 patients each. Group 1 received 20 mg paroxetine every day for 1 month, Group 2 received 20 mg tadalafil on demand 2 h before intercourse, and Group 3 received paroxetine and tadalafil on demand 2 h before intercourse. Intravaginal ejaculatory latency times (IELT) scores were evaluated at baseline, at the end of the first month of therapy and 1 month after discontinuation of the treatment, while International Index of Erectile Function (IIEF) questionnaire scores were evaluated both prior to and after the treatment. At the end of the first month of therapy, IELT scores were compared with the basal values and statistically significant changes were detected (60.6 ± 30.2-117.3 ± 67.3, 68.5 ± 21.4-110.2 ± 37.3, 71.56 ± 40.23-175.2 ± 60.2)(P < 0.01). IELT scores after discontinuation of treatment were found to be close to the baseline IELT scores (P > 0.05). IIEF scores were evaluated both prior to and after the treatment, and no statistically significant difference was detected (P > 0.05). It is concluded that utilisation of selective serotonin reuptake inhibitors (SSRI) and phosphodiesterase-5 inhibitors (PDE5i) combination before intercourse seems to provide significantly longer ejaculatory latency times as compared with SSRI alone for a long time in patients with PE.
dc.identifier.citationPolat, E. C., Özbek, E., Ötünçtemur, A., Özcan, L. ve Şimşek, A. (2015). Combination therapy with selective serotonin reuptake inhibitors and phosphodiesterase-5 inhibitors in the treatment of premature ejaculation. Andrologia, 47(5), 487-492. https://dx.doi.org/10.1111/and.12289
dc.identifier.doi10.1111/and.12289
dc.identifier.endpage492
dc.identifier.issn0303-4569
dc.identifier.issue5
dc.identifier.scopusqualityQ2
dc.identifier.startpage487
dc.identifier.urihttps://hdl.handle.net/20.500.12511/831
dc.identifier.urihttps://dx.doi.org/10.1111/and.12289
dc.identifier.volume47
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBlackwell Publishing
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectParoxetine
dc.subjectPDE5i
dc.subjectPE
dc.subjectSSRI
dc.subjectTadalafil
dc.titleCombination therapy with selective serotonin reuptake inhibitors and phosphodiesterase-5 inhibitors in the treatment of premature ejaculation
dc.typeArticle

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