Risk factors for gram-negative bacterial infection of cardiovascular implantable electronic devices: Multicentre observational study (CarDINe Study)

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dc.authorid0000-0001-8022-7325
dc.authorid0000-0003-4147-3587
dc.contributor.authorPascale, Renato
dc.contributor.authorToschi, Alice
dc.contributor.authorAslan, Abdullah Tarık
dc.contributor.authorMassaro, Giulia
dc.contributor.authorMaccaro, Angelo
dc.contributor.authorFabbricatore, Davide
dc.contributor.authorDell'Aquila, Andrea
dc.contributor.authorRipa, Marco
dc.contributor.authorIşık, Mehmet Emirhan
dc.contributor.authorUygun Kızmaz, Yeşim
dc.contributor.authorIacopino, Saverio
dc.date.accessioned2023-03-10T06:23:43Z
dc.date.available2023-03-10T06:23:43Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalı
dc.description.abstractBackground: Infections of cardiovascular implantable electronic devices (CIED) are mainly due to Gram-positive bacteria (GPB). Data about Gram-negative bacteria CIED (GNB-CIED) infections are limited. This study aimed to investigate risk factors, clinical and diagnostic characteristics, and outcome of patients with GNB-CIED. Methods: A multicentre, international, retrospective, case-control-control study was performed on patients undergoing CIED implantation from 2015 to 2019 in 17 centres across Europe. For each patient diagnosed with GNB-CIED, one matching control with GPB-CIED infection and two matching controls without infection were selected. Results: A total of 236 patients were enrolled: 59 with GNB-CIED infection, 59 with GPB-CIED infection and 118 without infection. No between-group differences were found regarding clinical presentation, diagnostic and therapeutic management. A trend toward a higher rate of fluorodeoxyglucose positron emission computed tomography (FDG PET/CT) positivity was observed among patients with GNB than in those with GPB-CIED infection (85.7% vs. 66.7%; P = 0.208). Risk factors for GNB-CIED infection were Charlson Comorbidity Index Score (relative risk reduction, RRR = 1.211; P = 0.011), obesity (RRR = 5.122; P = 0.008), ventricular-pacing ventricular-sensing inhibited-response pacemaker implantation (RRR = 3.027; P = 0.006) and right subclavian vein site of implantation (RRR = 5.014; P = 0.004). At 180-day survival analysis, GNB-CIED infection was associated with increased mortality risk (HR = 1.842; P = 0.067). Conclusions: Obesity, high number of comorbidities and right subclavian vein implantation site were associated with increased risk of GNB-CIED infection. A prompt therapeutic intervention that may be guided using FDG PET/CT is suggested in patients with GNB-CIED infection, considering the poorer outcome observed in this group.
dc.identifier.citationPascale, R., Toschi, A., Aslan, A. T., Massaro, G., Maccaro, A., Fabbricatore, D. ... Iacopino, S. (2023). Risk factors for gram-negative bacterial infection of cardiovascular implantable electronic devices: Multicentre observational study (CarDINe Study). International Journal of Antimicrobial Agents, 61(3). https://doi.org/10.1016/j.ijantimicag.2023.106734
dc.identifier.doi10.1016/j.ijantimicag.2023.106734
dc.identifier.issn0924-8579
dc.identifier.issn1872-7913
dc.identifier.issue3
dc.identifier.pmid36690123
dc.identifier.scopus2-s2.0-85149069850
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.ijantimicag.2023.106734
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10600
dc.identifier.volume61
dc.identifier.wos000946704400001en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYılmaz, Mesut
dc.institutionauthorŞahin, Meyha
dc.language.isoen
dc.publisherElsevier B.V.
dc.relation.ispartofInternational Journal of Antimicrobial Agentsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectGram-Negative
dc.subjectCardiovascular Implantable Electronic Devices
dc.subjectCIED Infection
dc.subjectEndocarditis
dc.subjectFDG PET/CT
dc.titleRisk factors for gram-negative bacterial infection of cardiovascular implantable electronic devices: Multicentre observational study (CarDINe Study)
dc.typeArticle

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