Demonstration of the protective effect of ghrelin in the livers of rats with cisplatin toxicity

Basit Öğe Kaydı
dc.authorid0000-0001-9378-4438
dc.contributor.authorBademci, Refik
dc.contributor.authorErdoğan, Mümin Alper
dc.contributor.authorEroğlu, Ersan
dc.contributor.authorMeral, Ayfer
dc.contributor.authorErdoğan, Arife
dc.contributor.authorAtasoy, Özüm
dc.contributor.authorErbaş, Oytun
dc.date.accessioned2021-12-22T08:27:01Z
dc.date.available2021-12-22T08:27:01Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.description.abstractDespite the various and newly developed chemotherapeutic agents in recent years, cisplatin is still used very frequently as a chemotherapeutic agent, even though cisplatin has toxic effects on many organs. The aim of our study is to show whether ghrelin reduces the liver toxicity of cisplatin in the rat model. Twenty-eight male Sprague Dawley albino mature rats were chosen to be utilized in the study. Group 1 rats (n = 7) were taken as the control group, and no medication was given to them. Group 2 rats (n = 7) received 5 mg/kg/day cisplatin and 1 ml/kg/day of 0.9% NaCl, Group 3 rats (n = 7) received 5 mg/kg/day cisplatin and 10 ng/kg/day ghrelin, Group 4 rats (n = 7) received 5 mg/kg/day cisplatin and 20 ng/kg/day ghrelin for 3 days. Glutathione, malondialdehyde (MDA), superoxide dismutase (SOD), plasma alanine aminotransferase (ALT) levels, and liver biopsy results were measured in rats. It was determined that, especially in the high-dose group, the MDA, plasma ALT, and SOD levels increased less in the ghrelin group as compared to the cisplatin group, and the glutathione level decreased slightly with a low dose of ghrelin, while it increased with a higher dose. In histopathological examination, it was determined that the toxic effect of cisplatin on the liver was reduced with a low dose of ghrelin, and its histopathological appearance was similar to normal liver tissue when given a high dose of ghrelin. These findings show that ghrelin, especially in high doses, can be used to reduce the toxic effect of cisplatin.
dc.identifier.citationBademci, R., Erdoğan, M. A., Eroğlu, E., Meral, A., Erdoğan, A., Atasoy, Ö. ... Erbaş, O. (2021). Demonstration of the protective effect of ghrelin in the livers of rats with cisplatin toxicity. Human and Experimental Toxicology, 40(12), 2178-2187. https://doi.org/10.1177/09603271211026722
dc.identifier.doi10.1177/09603271211026722
dc.identifier.endpage2187
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.issue12
dc.identifier.scopusqualityQ2
dc.identifier.startpage2178
dc.identifier.urihttps://doi.org/10.1177/09603271211026722
dc.identifier.urihttps://hdl.handle.net/20.500.12511/8709
dc.identifier.volume40
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSAGE Publications Inc.
dc.relation.ispartofHuman and Experimental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHepatotoxicity
dc.subjectCisplatin
dc.subjectGhrelin
dc.subjectAntioxidant
dc.subjectToxicity
dc.titleDemonstration of the protective effect of ghrelin in the livers of rats with cisplatin toxicity
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Bademci-Refik-2021.pdf
Boyut:
2.07 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu