Curcumin effects on cell proliferation, angiogenesis and metastasis in colorectal cancer

Basit Öğe Kaydı
dc.authorid0000-0002-0675-1839
dc.contributor.authorÇalıbaşı-Kocal, Gizem
dc.contributor.authorPakdemirli, Ahu
dc.contributor.authorBayrak, Serdar
dc.contributor.authorÖzüpek, Nazlı Mert
dc.contributor.authorSever, Tolga
dc.contributor.authorBaşbınar, Yasemin
dc.contributor.authorEllidokuz, Hülya
dc.contributor.authorYiğitbaşı, Türkan
dc.date.accessioned2019-12-20T13:14:42Z
dc.date.available2019-12-20T13:14:42Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractPurpose: Curcumin is a natural phytopolyphenol compound isolated from the root of turmeric (Curcuma longa) and possesses a wide range of biological properties. The purpose of this study was to evaluate the antiproliferative, wound healing, anti-invasive and anti-migrative effects of curcumin on HCT-116 and LoVo colorectal cancer cell lines. Methods: The antiproliferative activity of 2.5-75 µM curcumin was tested on HCT-116 and LoVo colorectal cell lines and the viability of the cells was tested with WST-1 reagent by using ELISA plate reader at 450 nm. xCELLigence RTCA DP system was used for the detection of anti-invasive and anti-migrative effects of curcumin. Results: The IC50 of curcumin was 10±0.03 for HCT-116 and 20±0.05 µM for LoVo cell lines. The IC50 of curcumin (10µM for HCT-116 and 20 µM for LoVo) showed anti-metastatic activity on these cell lines. Conclusion: This study showed that curcumin could be evaluated as a promising anti-cancer agent for human colorectal cancer.
dc.description.sponsorshipDokuz Eylul Universityen_US
dc.identifier.citationÇalıbaşı-Kocal, G., Pakdemirli, A., Bayrak, S., Özüpek, N. M., Sever, T., Başbınar, Y. ... Yiğitbaşı, T. (2019). Curcumin effects on cell proliferation, angiogenesis and metastasis in colorectal cancer. Journal of B.U.ON, 24(4), 1482-1487.
dc.identifier.endpage1487
dc.identifier.issn11070625
dc.identifier.issue4
dc.identifier.scopusqualityN/A
dc.identifier.startpage1482
dc.identifier.urihttps://hdl.handle.net/20.500.12511/4584
dc.identifier.volume24
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherZerbinis Publications
dc.relation.ispartofJournal of B.U.ONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectColorectal Cancer
dc.subjectCurcumin
dc.subjectInvasion
dc.subjectMigration
dc.subjectProliferation
dc.titleCurcumin effects on cell proliferation, angiogenesis and metastasis in colorectal cancer
dc.typeArticle

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