Synthesis of novel methyl jasmonate derivatives and evaluation of their biological activity in various cancer cell lines

Onur Sucu, Bilgesu; Savluğ İpek, Özgecan; Özdatlı Kurtuluş, Şükran; Yazıcı, Büşra Emine; Karakaş, Nihal; Güzel, Mustafa

Synthesis of novel methyl jasmonate derivatives and evaluation of their biological activity in various cancer cell lines

dc.authorid	0000-0002-9096-1512
dc.authorid	0000-0002-1423-0435
dc.contributor.author	Onur Sucu, Bilgesu
dc.contributor.author	Savluğ İpek, Özgecan
dc.contributor.author	Özdatlı Kurtuluş, Şükran
dc.contributor.author	Yazıcı, Büşra Emine
dc.contributor.author	Karakaş, Nihal
dc.contributor.author	Güzel, Mustafa
dc.date.accessioned	2019-12-25T11:43:30Z
dc.date.available	2019-12-25T11:43:30Z
dc.date.issued	2019
dc.department	İstanbul Medipol Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Eczane Hizmetleri Ana Bilim Dalı
dc.department	İstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.department	İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.department	İstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.description.abstract	Warburg hypothesized that the energy consumption of cancer cells is different than the normal cells. When compared to normal conditions, cancer cells do not undergo tricarboxylic acid (TCA) cycle therefore resulting in more lactate in the cells. Glycolysis pathway is a way of cancer cells to provide energy. The first step in glycolysis is the phosphorylation of glucose to glucose-6-phosphate. This reaction is catalyzed by the hexokinase-II enzyme (HK-II) which is known to be overexpressed in tumor cells. The feeding of cancer cells can be prevented by inhibiting the hexokinase-II enzyme in the first step of aerobic glycolysis. In literature, Methyl Jasmonate (MJ) is known as a Hexokinase-II inhibitor since it disposes VDAC and HK-II interaction on mitochondrial membrane. In our study, we aimed to increase the activity by synthesizing the novel MJ analogues with appropriate modifications. Here we report Hexokinase-2 enzyme and cell viability study results in different cancer cells. Based on the three different cancer cell lines we investigated, our novel MJ analogues proved to be more potent than the original molecule. Thus this research may provide more efficacious/ novel HK-II inhibitors and may shed light to develop new anti-cancer agents.
dc.description.sponsorship	Türkiye Bilimsel ve Teknolojik Araştırma Kurumu (TÜBİTAK)	en_US
dc.identifier.citation	Onur Sucu, B., Savluğ İpek, Ö., Özdatlı Kurtuluş, Ş., Yazıcı, B. E., Karakaş, N. ve Güzel, M. (2019). Synthesis of novel methyl jasmonate derivatives and evaluation of their biological activity in various cancer cell lines. Bioorganic Chemistry, 91. https://doi.org/10.1016/j.bioorg.2019.103146
dc.identifier.doi	10.1016/j.bioorg.2019.103146
dc.identifier.issn	1090-2120
dc.identifier.issn	0045-2068
dc.identifier.scopusquality	Q1
dc.identifier.uri	https://doi.org/10.1016/j.bioorg.2019.103146
dc.identifier.uri	https://hdl.handle.net/20.500.12511/4682
dc.identifier.volume	91
dc.identifier.wosquality	Q2
dc.indekslendigikaynak	Web of Science
dc.indekslendigikaynak	Scopus
dc.indekslendigikaynak	PubMed
dc.language.iso	en
dc.publisher	Academic Press Inc Elsevier Science
dc.relation.ec	info:eu-repo/grantAgreement/TUBITAK/215S890
dc.relation.ispartof	Bioorganic Chemistry	en_US
dc.relation.publicationcategory	Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Cancer Therapy
dc.subject	Aerobic Glycolysis
dc.subject	Warburg Effect
dc.subject	Hexokinase-II Inhibition
dc.subject	Methyl Jasmonate
dc.subject	Novel Drug Discovery and Development
dc.title	Synthesis of novel methyl jasmonate derivatives and evaluation of their biological activity in various cancer cell lines
dc.type	Article