Comparison of mesenchymal stem cells and autogenous cortical bone graft in the treatment of class II furcation defects in dogs

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dc.contributor.authorŞimşek, Selen Burçak
dc.contributor.authorÇayır Keleş, Gonca
dc.contributor.authorBarış, Sancar
dc.contributor.authorÖzkan Çetinkaya, Burcu
dc.date.accessioned2020-06-01T09:18:49Z
dc.date.available2020-06-01T09:18:49Z
dc.date.issued2012
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Periodontoloji Ana Bilim Dalı
dc.description.abstractThe purpose of this study was to compare the effectiveness of mesenchymal stem cells (MSCs) with platelet-rich plasma (PRP) as scaffold and autogenous cortical bone (ACB) graft with and without PRP in the regenerative treatment of class II furcation defects in dogs. The mandibular second, third, and fourth premolars (P2, P3, P4) and maxillary P3 and P4 of both sides in three dogs were selected for experimentation. Class II furcation defects (5 mm in height and 2 mm in depth) were surgically created. Five weeks after the first operation, scaling + root planning (group 1), PRP (group 2), ACB (group 3), combination of ACB/PRP (group 4), and combination of MSCs/PRP (group 5) treatments were performed during open flap debridement. The percentage of cementum and alveolar bone formation was evaluated by histomorphometric analysis after a healing period of 8 weeks. There was new cementum along with periodontal ligament and coronal growth of alveolar bone in all groups. Cementum formation was significantly higher in groups 3, 4, and 5 compared to the control group (P < 0.05) with no significant difference between groups 2, 3, 4, and 5. Alveolar bone formation was similar in all groups (P > 0.05). It can be concluded that periodontal regeneration with complete filling of class II furcation defects with cementum, alveolar bone, and periodontal ligament is obtained 8 weeks after ACB, ACB/PRP, and MSCs/PRP treatments; however, efficacy of none is higher than another.
dc.description.sponsorshipOndokuz Mayis Universityen_US
dc.identifier.citationŞimşek, S. B., Çayır Keleş, G., Barış, S. ve Özkan Çetinkaya, B. (2012). Comparison of mesenchymal stem cells and autogenous cortical bone graft in the treatment of class II furcation defects in dogs. Clinical Oral Investigations, 16(1), 251-258. https://dx.doi.org/10.1007/s00784-010-0486-7
dc.identifier.doi10.1007/s00784-010-0486-7
dc.identifier.endpage258
dc.identifier.issn1432-6981
dc.identifier.issue1
dc.identifier.scopusqualityQ1
dc.identifier.startpage251
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5245
dc.identifier.urihttps://dx.doi.org/10.1007/s00784-010-0486-7
dc.identifier.volume16
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofClinical Oral Investigationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAutogenous Bone Graft
dc.subjectFurcation Defects
dc.subjectMesenchymal Stem Cells
dc.subjectPeriodontal Regeneration
dc.subjectPlatelet-Rich Plasma
dc.titleComparison of mesenchymal stem cells and autogenous cortical bone graft in the treatment of class II furcation defects in dogs
dc.typeArticle

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