Clinicopathological and survival characteristics of mismatch repair status and PD-1 expression in serous ovarian cancer

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dc.authorid0000-0001-7934-7039
dc.contributor.authorÖlmez, Fatma
dc.contributor.authorOğlak, Süleyman Cemil
dc.contributor.authorAkgöl, Sedat
dc.contributor.authorÖlmez, Ömer Fatih
dc.contributor.authorBilici, Ahmet
dc.contributor.authorAkbayır, Özgür
dc.contributor.authorGedik Özköse, Zeynep
dc.contributor.authorCan, Esra
dc.contributor.authorÜnal, Ömer
dc.contributor.authorAcar Şirinoğlu, Hicran
dc.date.accessioned2023-07-13T11:25:04Z
dc.date.available2023-07-13T11:25:04Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractObjective: To evaluate the clinicopathological characteristics of mismatch repair (MMR) deficiency and its clinical outcomes by performing immunohistochemistry (IHC) for MMR genes in the serous ovarian cancer (SOC) tumour sections.Study Design: A retrospective case-control study. Place and Duration of the Study: Gynecology Department of Kanuni Sultan Suleyman Training and Research Hospital, and Department of Medical Oncology of Medipol University, between March 2001 and January 2020. Methodology: IHC was carried out for MLH1, MSH2, MSH6, and PMS2 on full-section slides from 127 SOCs to evaluate the MMR status. MMR-negative and MMR-low groups together were defined as MMR deficient and called microsatellite instability-high (MSI-H). The MSI status and expression of programmed cell death-1 (PD-1) were compared in SOCs with different MMR statuses. Results: A significantly higher frequency of MMR-deficient SOCs was diagnosed at early stages compared with the patients in the MSS group (38.6% and 20.6%, respectively, p=0.022). The frequency of cases with PD-1 expression was significantly higher in the MSI-H group (76.2%) than in the MSS counterparts (58.8%, p=0.028). Patients in the MSI-H group had significantly longer DFS (25.6 months) and OS (not reached) than those in the MSS group (16 months and 48.9 months, p=0.039 and p=0.026, respectively).Conclusion: MSI-H SOCs were diagnosed at an earlier stage as compared to MMR proficient cases. The presence of PD-1 expres-sion was significantly higher in cases presenting MMR deficiency compared with MMR-proficient cases. MSI status was significantly associated with DFS and OS.
dc.identifier.citationÖlmez, F., Oğlak, S. C., Akgöl, S., Ölmez, Ö. F., Bilici, A., Akbayır, Ö. ... Acar Şirinoğlu, H. (2023). Clinicopathological and survival characteristics of mismatch repair status and PD-1 expression in serous ovarian cancer. Journal of College of Physicians and Surgeons Pakistan (JCPSP), 33(6), 666-672. https://dx.doi.org/10.29271/jcpsp.2023.06.666
dc.identifier.doi10.29271/jcpsp.2023.06.666
dc.identifier.endpage672
dc.identifier.issn1022-386X
dc.identifier.issn1681-7168
dc.identifier.issue6
dc.identifier.pmid37300263
dc.identifier.scopus2-s2.0-85163906852
dc.identifier.scopusqualityQ3
dc.identifier.startpage666
dc.identifier.urihttps://dx.doi.org/10.29271/jcpsp.2023.06.666
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11193
dc.identifier.volume33
dc.identifier.wos001011668000013en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖlmez, Ömer Fatih
dc.institutionauthorBilici, Ahmet
dc.language.isoen
dc.publisherCollege of Physicians and Surgeons Pakistan
dc.relation.ispartofJournal of College of Physicians and Surgeons Pakistan (JCPSP)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSerous Ovarian Cancer
dc.subjectMicrosatellite Instability
dc.subjectMismatch Repair Deficiency
dc.titleClinicopathological and survival characteristics of mismatch repair status and PD-1 expression in serous ovarian cancer
dc.typeArticle

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