Acute flaccid myelitis outbreak through 2016-2018: A multicenter experience from Turkey

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dc.contributor.authorÜnver, Olcay
dc.contributor.authorTürkdoğan, Dilşad
dc.contributor.authorGüler, Serhat
dc.contributor.authorKipoğlu, Osman
dc.contributor.authorGüngör, Mesut
dc.contributor.authorPaketçi, Cem
dc.contributor.authorCarman, Kürşat Bora
dc.contributor.authorÖztürk, Gülten
dc.contributor.authorMaraş Genç, Hülya
dc.contributor.authorÖzkan, Mehpare
dc.contributor.authorOlgaç Dündar, Nihal
dc.contributor.authorIşık, Uğur
dc.contributor.authorKaratoprak, Elif
dc.contributor.authorKılıç, Betül
dc.contributor.authorÖzkale, Murat
dc.contributor.authorBayram, Erhan
dc.contributor.authorYarar, Coşkun
dc.contributor.authorSözen, Hatice Gülhan
dc.contributor.authorSager, Güneş
dc.contributor.authorSakarya Güneş, Ayfer
dc.contributor.authorKahraman Koytak, Pınar
dc.contributor.authorKaradağ Saygı, Evrim
dc.contributor.authorEkinci, Gazanfer
dc.contributor.authorSaltık, Sema
dc.contributor.authorÇalışkan, Mine
dc.contributor.authorKara, Bülent
dc.contributor.authorYiş, Uluç
dc.contributor.authorAydınlı, Nur
dc.date.accessioned2021-05-20T07:51:55Z
dc.date.available2021-05-20T07:51:55Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractAim: We aim to describe the demographic characteristics, etiology, neurophysiology, imaging findings, treatment, prognosis, and prognostic factors of acute flaccid myelitis. Methods: The clinical data, laboratory test and, magnetic resonance imaging (MRI) results of pediatric patients diagnosed with acute flaccid myelitis according to the Centers for Disease Control criteria between August 1, 2016, and December 31, 2018, from 13 centers in Turkey were reviewed. Results: Of the 34 cases identified, 31 were confirmed (91.2%). Eighteen patients (55.9%) were boys. The median patient age was 4 years (interquartile range 2.5–6.9 years). Most of the patients were admitted in 2018 (n = 27). A preceding history of a febrile illness was reported in all patients, with a median of 4 days (interquartile range 3–7 days) before symptom onset. Thirty-one patients had T2 hyperintensity on spinal MRI, and 18 patients had cerebrospinal fluid pleocytosis. The most common infectious agents were entero/rhinoviruses (n = 5) in respiratory specimens. All patients except one received immunotherapy either alone or in combination. Among 27 patients with follow-up data 24 had persistent weakness. Involvement of four limbs together with an abnormal brain MRI at onset were associated with a poor prognosis. Conclusion: The number of patients with acute flaccid myelitis increased since 2012, spiking with every 2-year interval, largely in the pediatric population. The median age decreases with every outbreak. Clinicians should be aware of the clinical picture for early collection of specimens and early start of rehabilitation programs. Further studies are needed to better characterize the etiology, pathogenesis, risk factors, and treatment of this rare condition.
dc.identifier.citationÜnver, O., Türkdoğan, D., Güler, S., Kipoğlu, O., Güngör, M., Paketçi, C. ... Aydınlı, N. (2021). Acute flaccid myelitis outbreak through 2016-2018: A multicenter experience from Turkey. European Journal of Paediatric Neurology, 30, 113-120. https://dx.doi.org/10.1016/j.ejpn.2020.10.011
dc.identifier.doi10.1016/j.ejpn.2020.10.011
dc.identifier.endpage120
dc.identifier.issn1090-3798
dc.identifier.issn1532-2130
dc.identifier.scopusqualityQ1
dc.identifier.startpage113
dc.identifier.urihttps://dx.doi.org/10.1016/j.ejpn.2020.10.011
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6853
dc.identifier.volume30
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Ltd.
dc.relation.ispartofEuropean Journal of Paediatric Neurologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAcute Flaccid Paralysis
dc.subjectEnterovirus D-68
dc.subjectPolio-Like Disease
dc.subjectEnterovirus
dc.titleAcute flaccid myelitis outbreak through 2016-2018: A multicenter experience from Turkey
dc.typeArticle

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