Inflammatory and Hematologic Liver and Platelet (HALP) Scores in Hypothermia-Treated Hypoxic–Ischemic Encephalopathy (HIE)

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dc.authorid0000-0001-8984-9673
dc.contributor.authorHakyemez Toptan, Handan
dc.contributor.authorTezel, Kübra Gökçe
dc.contributor.authorTezel, Oğuzhan
dc.contributor.authorAtaç, Ömer
dc.contributor.authorVardar, Gonca
dc.contributor.authorGülcan Kersin, Sinem
dc.contributor.authorÖzek, Eren
dc.date.accessioned2024-02-02T11:00:14Z
dc.date.available2024-02-02T11:00:14Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Halk Sağlığı Ana Bilim Dalı
dc.description.abstractObjective: This study examined systemic inflammatory indices and “Hemoglobin, Albumin, Lymphocyte, Platelet (HALP) scores” in neonates with hypoxic–ischemic encephalopathy (HIE). Methods: A total of 43 neonates with moderate-to-severe HIE at 36 weeks’ gestation were assessed. Systemic inflammatory markers were measured before HT commenced within 0–6 h after birth and between 60 and 72 h during and after therapy or before adjusting for hypothermia. Results: Platelet counts, hemoglobin levels, and platelet indices in the HIE group were significantly lower at both time points (p = 0.001). Both the neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR) decreased in the HIE group after hypothermia therapy (p = 0.001). Seizures, PVL, and kidney injuries were associated with higher HALP scores. The AUCs of NLR, PLR, MLR, SII, SIRI, and platelet, neutrophil, monocyte, and lymphocyte Index (PIV) showed significant sensitivity and specified HIE, with area under the curve (AUC) values of 0.654, 0.751, 0.766, 0.700, 0.722, and 0.749, respectively. Conclusions: A significant difference in systemic inflammatory markers was found between the HIE and control groups after hypothermia treatment, with significant reductions in the MLR and NLR. These markers, particularly MLR, were significant predictors of adverse clinical outcomes including seizures, PVL, and kidney damage.
dc.identifier.citationHakyemez Toptan, H., Tezel, K. G., Tezel, O., Ataç, Ö., Vardar, G., Gülcan Kersin, S. ... Özek, E. (2024). Inflammatory and Hematologic Liver and Platelet (HALP) Scores in Hypothermia-Treated Hypoxic–Ischemic Encephalopathy (HIE). Children, 11(1). https://dx.doi.org/10.3390/children11010072
dc.identifier.doi10.3390/children11010072
dc.identifier.issn2227-9067
dc.identifier.issue1
dc.identifier.pmid38255385
dc.identifier.scopus2-s2.0-85183119243
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://dx.doi.org/10.3390/children11010072
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12244
dc.identifier.volume11
dc.identifier.wos001148910600001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAtaç, Ömer
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relation.ispartofChildrenen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectHypoxic–Ischemic Encephalopathy
dc.subjectSystemic Inflammatory Indices
dc.subjectHALP Score
dc.subjectNeonatal Care
dc.subjectHypothermia Therapy
dc.titleInflammatory and Hematologic Liver and Platelet (HALP) Scores in Hypothermia-Treated Hypoxic–Ischemic Encephalopathy (HIE)
dc.typeArticle

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