Development of mucoadhesive modified kappa-carrageenan/pectin patches for controlled delivery of drug in the buccal cavity

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dc.authorid0000-0001-8267-0435
dc.contributor.authorÖzkahraman, Bengi
dc.contributor.authorÖzbaş, Zehra
dc.contributor.authorYaşayan, Gökçen
dc.contributor.authorAkgüner, Zeynep Püren
dc.contributor.authorYarımcan, Filiz
dc.contributor.authorAlarçin, Emine
dc.contributor.authorBal Öztürk, Ayça
dc.date.accessioned2022-12-27T09:32:13Z
dc.date.available2022-12-27T09:32:13Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı
dc.description.abstractIn this study, modified kappa-carrageenan/pectin hydrogel patches were fabricated for treatment of buccal fungal infections. For this purpose, kappa-carrageenan-g-acrylic acid was modified with different thiolated agents (L-cysteine and 3-mercaptopropionic acid), and the thiol content of the resulting modified kappa-carrageenan was confirmed by elemental analyzer. Then, the hydrogel patches were fabricated, and characterized by Fourier-transform infrared spectroscopy, thermogravimetric analysis, ex vivo mucoadhesion test, and swelling behavior. Triamcinolone acetonide was added either directly or by encapsulating within the poly(lactic-co-glycolic acid) nanoparticles. The release amount of the drug from the directly loaded patch was 7.81 mg/g polymer, while it was 3.28 mg/g polymer for the encapsulated patch with the same content at 7 hr. The hydrogel patches had no cytotoxicity by cell culture studies. Finally, the drug loaded hydrogel patches were demonstrated antifungal activity against Aspergillus fumigatus and Aspergillus flavus. These results provide that the novel modified kappa-carrageenan and pectin based buccal delivery system has promising antifungal property, and could have advantages compared to conventional buccal delivery systems.
dc.identifier.citationÖzkahraman, B., Özbaş, Z., Yaşayan, G., Akgüner, Z. P., Yarımcan, F., Alarçin, E. ... Bal Öztürk, A. (2022). Development of mucoadhesive modified kappa-carrageenan/pectin patches for controlled delivery of drug in the buccal cavity. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 110(4), 787-798. https://doi.org/10.1002/jbm.b.34958
dc.identifier.doi10.1002/jbm.b.34958
dc.identifier.endpage798
dc.identifier.issn1552-4973
dc.identifier.issn1552-4981
dc.identifier.issue4
dc.identifier.pmid34846796
dc.identifier.scopus2-s2.0-85120158755
dc.identifier.scopusqualityQ2
dc.identifier.startpage787
dc.identifier.urihttps://doi.org/10.1002/jbm.b.34958
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10192
dc.identifier.volume110
dc.identifier.wos000723711600001en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYarımcan, Filiz
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Biomedical Materials Research - Part B Applied Biomaterialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/218M064
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAntifungal Activity
dc.subjectBuccal Drug Delivery
dc.subjectThiolated Kappa-Carrageenan
dc.subjectTriamcinolone Acetonide
dc.titleDevelopment of mucoadhesive modified kappa-carrageenan/pectin patches for controlled delivery of drug in the buccal cavity
dc.typeArticle

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