Efficacy of chitosan powder in reducing vaginal bleeding following a loop electrosurgical excision procedure: a randomized control trial

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dc.contributor.authorGüngördük, Kemal
dc.contributor.authorÜnver, Hikmet Can
dc.contributor.authorŞahin Uyar, Berican
dc.contributor.authorErgü, Berke Nur
dc.contributor.authorGülseren, Varol
dc.contributor.authorÖzdemir, İsa Aykut
dc.date.accessioned2025-12-01T12:00:44Z
dc.date.available2025-12-01T12:00:44Z
dc.date.issued2025
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.description.abstractObjective: To evaluate the efficacy of topical chitosan powder in reducing postoperative vaginal bleeding following a loop electrosurgical excision procedure (LEEP). Methods: In this randomized controlled trial, patients who underwent LEEP were randomly assigned (1:1) to the chitosan group, in which the wound area was sprayed with chitosan powder using a spray pump, or the control group. The primary outcome was the median quantity of vaginal blood lost in the early postoperative period (defined as within 6 h of the procedure). Results: The 124 women enrolled in the study were randomly divided into control (n = 61) and chitosan (n = 63) groups. The median amount of vaginal blood loss during the early postoperative period was significantly lower in the chitosan group than in the control group (198.85 [64.4–388.57] mL vs. 250.60 [67.7–552.87] mL; P < 0.001). The rate of late postoperative bleeding requiring hemostatic intervention was also lower in the chitosan group than in the control group (3.2% vs. 16.4%; P = 0.013). Superior cervical wound healing in the chitosan group compared to the control group was also observed. Conclusion: The application of chitosan powder to the cervical wound bed can improve surgical outcomes by decreasing post-LEEP vaginal bleeding and facilitating the healing of cervical wounds.
dc.identifier.citationGüngördük, K., Ünver, H. C., Şahin Uyar, B., Ergü, B. N., Gülseren, V. ve Özdemir, İ. A. (2025). Efficacy of chitosan powder in reducing vaginal bleeding following a loop electrosurgical excision procedure: a randomized control trial. International Journal of Gynecology and Obstetrics, 169(1), 240-246. http://dx.doi.org/10.1002/ijgo.16055
dc.identifier.doi10.1002/ijgo.16055
dc.identifier.endpage246
dc.identifier.issn0020-7292
dc.identifier.issn1879-3479
dc.identifier.issue1
dc.identifier.pmid39614700
dc.identifier.scopus2-s2.0-85210587019
dc.identifier.scopusqualityQ2
dc.identifier.startpage240
dc.identifier.urihttp://dx.doi.org/10.1002/ijgo.16055
dc.identifier.urihttps://hdl.handle.net/20.500.12511/13258
dc.identifier.volume169
dc.identifier.wosWOS:001367800200001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzdemir, İsa Aykut
dc.institutionauthorid0000-0001-5457-3312
dc.language.isoen
dc.relation.ispartofInternational Journal of Gynecology and Obstetrics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChitosan
dc.subjectLoop Electrosurgical Excision Procedure
dc.subjectVaginal Bleeding
dc.titleEfficacy of chitosan powder in reducing vaginal bleeding following a loop electrosurgical excision procedure: a randomized control trial
dc.typeArticle

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