Focal laser ablation as clinical treatment of prostate cancer: Report from a Delphi consensus project

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dc.authorid0000-0002-6308-1763
dc.contributor.authorvan Luijtelaar, Annemarijke
dc.contributor.authorGreenwood, Bernadette Marie
dc.contributor.authorAhmed, Hashim Uddin
dc.contributor.authorBarqawi, Al Baha
dc.contributor.authorBarret, Éric
dc.contributor.authorBomers, Joyce G.R.
dc.contributor.authorBrausi, Maurizio
dc.contributor.authorChoyke, Peter L.
dc.contributor.authorCooperberg, Matthew R.
dc.contributor.authorEggener, Scott E.
dc.contributor.authorFeller, John Francis
dc.contributor.authorFrauscher, Ferdinand
dc.contributor.authorGeorge, Arvin Koruthu
dc.contributor.authorHindley, Richard Graham
dc.contributor.authorJenniskens, Sjoerd F.M.
dc.contributor.authorKlotz, Laurence
dc.contributor.authorKovacs, Gyoergy
dc.contributor.authorLindner, Uri
dc.contributor.authorLoeb, Stacy
dc.contributor.authorMargolis, Daniel Jason Aaron
dc.contributor.authorMarks, Leonard S.
dc.contributor.authorMay, Stuart
dc.contributor.authorMcClure, Timothy D.
dc.contributor.authorMontironi, Rodolfo
dc.contributor.authorNour, Sherif Gamal
dc.contributor.authorOto, Aytekin
dc.contributor.authorPolascik, Thomas James
dc.contributor.authorRastinehad, Ardeshir R.
dc.contributor.authorde Reyke, T. M.
dc.contributor.authorReijnen, Jeroen Sebastiaan
dc.contributor.authorde la Rosette, Jean J. M. C. H.
dc.contributor.authorSedelaar, John Pieter Michiel
dc.contributor.authorSperling, Dan S.
dc.contributor.authorWalser, Eric M.
dc.contributor.authorWard, John F.
dc.contributor.authorVillers, Arnauld A.
dc.contributor.authorGhai, Sangeet
dc.contributor.authorFütterer, Jürgen Jacobus
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:35:35Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:35:35Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.description.abstractPurpose: To define the role of focal laser ablation (FLA) as clinical treatment of prostate cancer (PCa) using the Delphi consensus method. Methods: A panel of international experts in the field of focal therapy (FT) in PCa conducted a collaborative consensus project using the Delphi method. Experts were invited to online questionnaires focusing on patient selection and treatment of PCa with FLA during four subsequent rounds. After each round, outcomes were displayed, and questionnaires were modified based on the comments provided by panelists. Results were finalized and discussed during face-to-face meetings. Results: Thirty-seven experts agreed to participate, and consensus was achieved on 39/43 topics. Clinically significant PCa (csPCa) was defined as any volume Grade Group 2 [Gleason score (GS) 3+4]. Focal therapy was specified as treatment of all csPCa and can be considered primary treatment as an alternative to radical treatment in carefully selected patients. In patients with intermediate-risk PCa (GS 3+4) as well as patients with MRI-visible and biopsy-confirmed local recurrence, FLA is optimal for targeted ablation of a specific magnetic resonance imaging (MRI)-visible focus. However, FLA should not be applied to candidates for active surveillance and close follow-up is required. Suitability for FLA is based on tumor volume, location to vital structures, GS, MRI-visibility, and biopsy confirmation. Conclusion: Focal laser ablation is a promising technique for treatment of clinically localized PCa and should ideally be performed within approved clinical trials. So far, only few studies have reported on FLA and further validation with longer follow-up is mandatory before widespread clinical implementation is justified.
dc.identifier.citationvan Luijtelaar, A., Greenwood, B. M., Ahmed, H. U., Barqawi, A. B., Barret, É., Bomers, J. G.R. ... Fütterer, J. J. (2019). Focal laser ablation as clinical treatment of prostate cancer: Report from a Delphi consensus project. World Journal of Urology, 37(10), 2147-2153. https://dx.doi.org/10.1007/s00345-019-02636-7
dc.identifier.doi10.1007/s00345-019-02636-7
dc.identifier.endpage2153
dc.identifier.issn0724-4983
dc.identifier.issue10
dc.identifier.scopusqualityQ1
dc.identifier.startpage2147
dc.identifier.urihttps://hdl.handle.net/20.500.12511/856
dc.identifier.urihttps://dx.doi.org/10.1007/s00345-019-02636-7
dc.identifier.volume37
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Verlag
dc.relation.ispartofWorld Journal of Urologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectConsensus
dc.subjectDelphi
dc.subjectFocal Laser Ablation
dc.subjectLaser Focal Therapy
dc.subjectProstate Cancer
dc.titleFocal laser ablation as clinical treatment of prostate cancer: Report from a Delphi consensus project
dc.typeArticle

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