Evaluation of the interaction between proliferation, oxidant-antioxidant status, Wnt pathway, and apoptosis in zebrafish embryos exposed to silver nanoparticles used in textile industry

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dc.authorid0000-0003-0804-1475
dc.authorid0000-0001-8089-1330
dc.authorid0000-0002-0675-1839
dc.contributor.authorEryılmaz, Oğuz
dc.contributor.authorAteş, Perihan Seda
dc.contributor.authorÜnal, İsmail
dc.contributor.authorÜstündağ, Ünsal Veli
dc.contributor.authorBay, Sadık
dc.contributor.authorAlturfan, Ahmet Ata
dc.contributor.authorYiğitbaşı, Türkan
dc.contributor.authorEmekli Alturfan, Ebru
dc.contributor.authorAkalın, Mehmet
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:57:25Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:57:25Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.descriptionWOS: 000419943200015
dc.descriptionPubMed ID: 29283201
dc.description.abstractAntimicrobial textile products are developing rapidly as an important part of functional textiles. Silver nanoparticles (AgNPs) are nanotechnology products with antimicrobial properties. However, exposure to nanoparticles in daily life is an important issue for public health, still being updated. Aim was to evaluate the effects of AgNPs on the development of zebrafish embryos focusing on Wnt pathway, proliferation, oxidant-antioxidant status, and apoptosis. The expressions of ccnd1 and gsk3 beta were determined by RT-PCR, whereas beta-catenin and proliferative cell antigen (PCNA) expressions were determined immunohistochemically. Lipid peroxidation, superoxide dismutase, and glutathione-S-transferase activities were determined spectrophotometrically. Apoptosis was determined using acridine orange staining. Oxidant status, apoptosis, immunohistochemical PCNA, and beta-catenin staining increased, whereas ccnd1 and antioxidant enzyme activities decreased in AgNPs-exposed embryos in a dose-dependent manner. Our results indicate the interaction of possible mechanisms that may be responsible for the toxic effects of AgNPs in zebrafish embryos.
dc.identifier.citationEryılmaz, O., Ateş, P. S., Ünal, İ., Üstündağ, Ü. V., Bay, S., Alturfan, A. A., ... Akalın, M. (2018). Evaluation of the interaction between proliferation, oxidant-antioxidant status, Wnt pathway, and apoptosis in zebrafish embryos exposed to silver nanoparticles used in textile industry. Journal of Biochemical and Molecular Toxicology, 32(1). https://dx.doi.org/10.1002/jbt.22015
dc.identifier.doi10.1002/jbt.22015
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue1
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://dx.doi.org/10.1002/jbt.22015
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2971
dc.identifier.volume32
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Biochemical and Molecular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectApoptosis
dc.subjectOxidant-Antioxidant Status
dc.subjectSilver Nanoparticles
dc.subjectWnt Pathway
dc.subjectZebrafish Embryo
dc.titleEvaluation of the interaction between proliferation, oxidant-antioxidant status, Wnt pathway, and apoptosis in zebrafish embryos exposed to silver nanoparticles used in textile industry
dc.typeArticle

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