Minocycline increases in-vitro cortical neuronal cell survival after laser induced axotomy

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dc.authorid0000-0002-1079-8832
dc.authorid0000-0002-5955-5356
dc.authorid0000-0003-4228-4577
dc.authorid0000-0003-4292-5717
dc.authorid0000-0001-6494-8923
dc.contributor.authorYuluğ, Burak
dc.contributor.authorOzansoy, Mehmet
dc.contributor.authorAlökten, Merve
dc.contributor.authorÇetin Ozansoy, Muzaffer Beyza
dc.contributor.authorÇankaya, Şeyda
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorKılıç, Ülkan
dc.contributor.authorKılıç, Ertuğrul
dc.date.accessioned2020-03-23T11:36:09Z
dc.date.available2020-03-23T11:36:09Z
dc.date.issued2020
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.description.abstractAntibiotic therapies targeting multiple regenerative mechanisms have the potential for neuroprotective effects, but the diversity of experimental strategies and analyses of non-standardised therapeutic trials are challenging. In this respect, there are no cases of successful clinical application of such candidate molecules when it comes to human patients. To address this problem, we tested minocycline in an in-vitro model of laser-axotomy. Here, we have shown that minocycline exerted a significant neuroprotective effect at 1 and 100?M doses. Beyond confirming the neuroprotective effect of minocycline in a more standardised and advanced in-vitro trauma model, our findings could have important implications for future studies that concentrate on the translational block between animal and human studies. Such sophisticated approaches might also help to conquer the influence of human-made variabilities in critical experimental injury models. To the best of our knowledge, this is the first study showing that minocycline increases in-vitro neuronal cell survival after laser-axotomy.
dc.identifier.citationYuluğ, B., Ozansoy, M., Alökten, M., Çetin Ozansoy, M. B., Çankaya, S., Hanoğlu, L. ... Kılıç, E. (2020). Minocycline increases in-vitro cortical neuronal cell survival after laser induced axotomy. Current Clinical Pharmacology, 15(2), 105-109. http://doi.org/10.2174/1574884714666190226093119
dc.identifier.doi10.2174/1574884714666190226093119
dc.identifier.endpage109
dc.identifier.issue2
dc.identifier.scopusqualityQ2
dc.identifier.startpage105
dc.identifier.urihttp://doi.org/10.2174/1574884714666190226093119
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5077
dc.identifier.volume15
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.relation.ispartofCurrent Clinical Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectIn-Vitro Cortical Cell Culture
dc.subjectLaser-Axotomy
dc.subjectMinocycline
dc.subjectTranslational Neuroscience
dc.titleMinocycline increases in-vitro cortical neuronal cell survival after laser induced axotomy
dc.typeArticle

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