Trimethylamine n-oxide (tmao) and tnf-α levels in periodontal disease associated with smoking

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dc.contributor.authorBal, İpek
dc.contributor.authorBalcı, Nur
dc.contributor.authorSorguç, Cem
dc.contributor.authorUslu Toygar, Hilal
dc.contributor.authorCeran Serdar, Ceyhan
dc.contributor.authorKurgan, Şivge
dc.contributor.authorSerdar, Muhittin
dc.date.accessioned2026-05-15T12:00:45Z
dc.date.available2026-05-15T12:00:45Z
dc.date.issued2025
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Periodontoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, Periodontoloji Ana Bilim Dalı
dc.description.abstractAims: Trimethylamine N-oxide (TMAO) is a compound involved in the pathogenesis of various systemic inflammatory diseases, including cardiovascular conditions. The aim of this study was to determine differences in saliva and serum levels of TMAO between periodontitis and healthy patients according to smoking status. Methods: The study included four systemically healthy groups: periodontally healthy non-smokers (NS-Control; n = 25), non-smokers with Stage-III-Grade-B periodontitis (NS-Periodontitis; n = 25), periodontally healthy smokers (S-Control; n = 25), and smokers with Stage-III Grade-C periodontitis (S-Periodontitis; n = 25). Periodontal parameters were recorded. TMAO levels were determined in saliva and serum samples using liquid chromatography-mass spectrometry (LC–MS/MS). TNF-α levels were measured by the ELISA method. Results: Salivary TNF-α and TMAO levels were significantly elevated in the smoking periodontitis group compared to other groups (p < 0.001 and p = 0.003, respectively). Serum TMAO levels were also significantly higher in the smoking periodontitis group compared to non-smoking controls and non-smoking periodontitis. TMAO/SFR ratios were notably higher in the smoking periodontitis group compared to other groups, and a strong positive correlation was observed between salivary TMAO and TNF-α levels (r = 0.892, p < 0.001). Conclusion: The data suggested that TMAO and TNF-α are associated with inflammatory mechanisms of periodontitis in cases where periodontitis coexists with smoking. Trial Registration: NCT06580431.
dc.identifier.citationBal, İ., Balcı, N., Sorguç, C., Uslu Toygar, H., Ceran Serdar, C., Kurgan, Ş. ... Serdar, M. (2025). Trimethylamine n-oxide (tmao) and tnf-α levels in periodontal disease associated with smoking. Oral Diseases, 31(7), 2282-2292. http://dx.doi.org/10.1111/odi.15262
dc.identifier.doi10.1111/odi.15262
dc.identifier.endpage2292
dc.identifier.issn1354-523X
dc.identifier.issn1601-0825
dc.identifier.issue7
dc.identifier.pmid39887517
dc.identifier.scopus2-s2.0-85216453099
dc.identifier.scopusqualityQ1
dc.identifier.startpage2282
dc.identifier.urihttp://dx.doi.org/10.1111/odi.15262
dc.identifier.urihttps://hdl.handle.net/20.500.12511/13452
dc.identifier.volume31
dc.identifier.wosWOS:001410838700001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBal, İpek
dc.institutionauthorBalcı, Nur
dc.institutionauthorSorguç, Cem
dc.institutionauthorUslu Toygar, Hilal
dc.institutionauthorid0000-0001-7986-7085
dc.institutionauthorid0000-0001-7409-1484
dc.language.isoen
dc.relation.ispartofOral Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPeriodontitis
dc.subjectSmoking
dc.subjectTMAO
dc.subjectTNF-Α
dc.titleTrimethylamine n-oxide (tmao) and tnf-α levels in periodontal disease associated with smoking
dc.typeArticle

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