The relationship between positron emission tomography-computed tomography imaging and histopathological features of thyroid incidentalomas detected during follow-up for primary malignancy

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dc.contributor.authorUstaalıoğlu Öven, Başak
dc.contributor.authorKılıçoğlu, Zeynep Gamze
dc.contributor.authorBilici, Ahmet Erkan
dc.contributor.authorTato?lu, Mehmet Tarık
dc.contributor.authorCanberk, Şule
dc.contributor.authorTilki, Metin
dc.contributor.authorAker Vardar, Fügen
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:57:31Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:57:31Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000470851300023
dc.descriptionPubMed ID: 31169225
dc.description.abstractAim of the Study: While the rate of thyroid incidentaloma detected on positron emission tomography (PET) was reported as 4%, the malignancy rate was 14%u50%. We evaluated the thyroid nodules which were detected by PET-computerized tomography (CT) in cancer patients and analyzed the pathological results of those thyroid nodules diagnosed by fine needle aspiration biopsy (FNAB) and their correlation with the maximum standardized uptake (SUVmax) value and PET imaging features. Materials and Methods: FNAB were performed for 40 thyroid incidentalomas. We analyzed the relationship between the histopathological findings and radiological features by Pearson's correlations and Chi-square-Fisher's exact tests to evaluate the factors associated with SUVmax. Results: The median SUVmax values were 5.4 for thyroid nodules. Totally, 14 malignancies were detected by FNAB (35%).The sensitivity and specificity of SUVmax value for diagnosis of malignancy were 87.5% and 52%, respectively. Positive and negative predictive values were 36.8% and 92.8%. The most common malignant and benign pathologies were classic variant papillary carcinoma and benign colloidal nodule. The median SUVmax was the higher in colon cancer thyroid metastasis and oncocytic neoplasia (SUVmax 14.5 and 13.6, respectively). Histopathological type was not related with nodule size but positively associated with categorical SUVmax(r = 0.318, P = 0.04) and negatively correlated with both the density of the thyroid nodule in PET-CT (r = 0.0042, P = 0.01) and density of nodule in ultrasound (USG) (r = 0.305, P = 0.05). Margin of the thyroid nodule in USG (P = 0.007) and internal component of the nodule in PET (P = 0.03) were found to be important factors to differentiate benign or malignant lesion. Conclusion: If the thyroid nodule is detected with flouro-2-deoxy-D-glucose uptake, to differentiate benign nodule from malignant, cytological examination is noteworthy to diagnose the more aggressive type of thyroid nodule and also thyroid metastasis from primary cancer.
dc.identifier.citationUstaalıoğlu Öven, B., Kılıçoğlu, Z. G., Bilici, A. E., Tatoğlu, M. T., Canberk, Ş., Tilki, M. ... Aker Vardar, F. (2019). The relationship between positron emission tomography-computed tomography imaging and histopathological features of thyroid incidentalomas detected during follow-up for primary malignancy. Journal of Cancer Research and Therapeutics, 15(3), 589-595. https://dx.doi.org/10.4103/jcrt.JCRT_889_16
dc.identifier.doi10.4103/jcrt.JCRT_889_16
dc.identifier.endpage595
dc.identifier.issn0973-1482
dc.identifier.issn1998-4138
dc.identifier.issue3
dc.identifier.scopusqualityQ2
dc.identifier.startpage589
dc.identifier.urihttps://dx.doi.org/10.4103/jcrt.JCRT_889_16
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2994
dc.identifier.volume15
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofJournal of Cancer Research and Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectBiopsy
dc.subjectMalignancy
dc.subjectPositron Emission Tomography-Computerized Tomography
dc.subjectThyroid Incidentaloma
dc.titleThe relationship between positron emission tomography-computed tomography imaging and histopathological features of thyroid incidentalomas detected during follow-up for primary malignancy
dc.typeArticle

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