Current practices of craniospinal irradiation techniques in Turkey: a comprehensive dosimetric analysis

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dc.authorid0000-0002-7794-8145
dc.authorid0000-0003-1752-7020
dc.contributor.authorŞenkesen, Öznur
dc.contributor.authorTezcanlı, Evrim
dc.contributor.authorAlkaya, Fadime
dc.contributor.authorİspir, Burçin
dc.contributor.authorÇatlı, Serap
dc.contributor.authorYeşil, Abdullah
dc.contributor.authorBezirganoğlu, Ebrar
dc.contributor.authorTuran, Sezgi
dc.contributor.authorKöksal, Canan
dc.contributor.authorGüray, Gülay
dc.contributor.authorHacıislamoğlu, Emel
dc.contributor.authorDurmuş, İsmail Faruk
dc.contributor.authorÇavdar, Şeyma
dc.contributor.authorAksu, Telat
dc.contributor.authorÇolak, Nurten
dc.contributor.authorKüçükmorkoç, Esra
dc.contributor.authorDoğan, Mustafa
dc.contributor.authorErcan, Tülay
dc.contributor.authorKaraköse, Fatih
dc.contributor.authorAlpan, Vildan
dc.contributor.authorCeylan, Cemile
dc.contributor.authorPoyraz, Gökhan
dc.contributor.authorNalbant, Nilgül
dc.contributor.authorKınay, Şeyda
dc.contributor.authorİpek, Servet
dc.contributor.authorKayalılar, Namık
dc.contributor.authorTatlı, Hamza
dc.contributor.authorZhu, Mingyao
dc.date.accessioned2024-05-17T08:37:30Z
dc.date.available2024-05-17T08:37:30Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyasyon Onkolojisi Ana Bilim Dalı
dc.description.abstractObjective: This study evaluates various craniospinal irradiation (CSI) techniques used in Turkish centers to understand their advantages, disadvantages and overall effectiveness, with a focus on enhancing dose distribution. Methods: Anonymized CT scans of adult and pediatric patients, alongside target volumes and organ-at-risk (OAR) structures, were shared with 25 local radiotherapy centers. They were tasked to develop optimal treatment plans delivering 36 Gy in 20 fractions with 95% PTV coverage, while minimizing OAR exposure. The same CT data was sent to a US proton therapy center for comparison. Various planning systems and treatment techniques (3D conformal RT, IMRT, VMAT, tomotherapy) were utilized. Elekta Proknow software was used to analyze parameters, assess dose distributions, mean doses, conformity index (CI), and homogeneity index (HI) for both target volumes and OARs. Comparisons were made against proton therapy. Results: All techniques consistently achieved excellent PTV coverage (V95 > 98%) for both adult and pediatric patients. Tomotherapy closely approached ideal Dmean doses for all PTVs, while 3D-CRT had higher Dmean for PTV_brain. Tomotherapy excelled in CI and HI for PTVs. IMRT resulted in lower pediatric heart, kidney, parotid, and eye doses, while 3D-CRT achieved the lowest adult lung doses. Tomotherapy approached proton therapy doses for adult kidneys and thyroid, while IMRT excelled for adult heart, kidney, parotid, esophagus, and eyes. Conclusion: Modern radiotherapy techniques offer improved target coverage and OAR protection. However, 3D techniques are continued to be used for CSI. Notably, proton therapy stands out as the most efficient approach, closely followed by Tomotherapy in terms of achieving superior target coverage and OAR protection.
dc.identifier.citationŞenkesen, Ö., Tezcanlı, E., Alkaya, F., İspir, B., Çatlı, S., Yeşil, A. ... Zhu, M. (2024). Current practices of craniospinal irradiation techniques in Turkey: a comprehensive dosimetric analysis. Radiation Oncology, 19(1). http://dx.doi.org/10.1186/s13014-024-02435-4
dc.identifier.doi10.1186/s13014-024-02435-4
dc.identifier.issn1748-717X
dc.identifier.issue1
dc.identifier.pmid38627747
dc.identifier.scopus2-s2.0-85190604115
dc.identifier.scopusqualityQ1
dc.identifier.urihttp://dx.doi.org/10.1186/s13014-024-02435-4
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12477
dc.identifier.volume19
dc.identifier.wos001204533300001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAlkaya, Fadime
dc.institutionauthorPoyraz, Gökhan
dc.language.isoen
dc.relation.ispartofRadiation Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/.*
dc.subjectCraniospinal Irradiation
dc.subjectIntensity-Modulated Radiation Therapy
dc.subjectProton Therapy
dc.subjectSecondary Cancer Risk
dc.subjectTomotherapy
dc.subjectVolumetric Modulated Arc Therapy
dc.titleCurrent practices of craniospinal irradiation techniques in Turkey: a comprehensive dosimetric analysis
dc.typeArticle

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