The effect of haemoglobin, albumin, lymphocyte and platelet score on the prognosis in patients with multiple myeloma

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dc.authorid0000-0001-9636-4113
dc.contributor.authorSolmaz, Şerife
dc.contributor.authorUzun, Özcan
dc.contributor.authorSevindik, Ömür Gökmen
dc.contributor.authorDemirkan, Fatih
dc.contributor.authorÖzcan, Mehmet Ali
dc.contributor.authorÖzsan, Güner Hayri
dc.contributor.authorAlacacıoğlu, İnci
dc.date.accessioned2023-02-08T09:57:26Z
dc.date.available2023-02-08T09:57:26Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractIntroduction In multiple myeloma cases, a variety of prognostic parameters have been identified, which contain the Durie-Salmon classification and the international staging system (ISS) that takes the serum ss2 microglobulin and albumin levels, platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and monocyte-to-lymphocyte ratio (MLR). This study investigates the effect of haemoglobin, albumin, lymphocyte and platelet (HALP) score which is a marker of inflammation status and nutrition, at the time of diagnosis for the patients with multiple myeloma on prognosis. Methods A total of 200 multiple myeloma patients with HALP scores calculated from serum haemoglobin, albumin, lymphocyte count and platelet levels at the time of diagnosis were retrospectively examined. The effect of HALP score on overall survival (OS) and progression-free survival and its relationship between the previously evaluated prognostic parameters were investigated. Results The optimal cut-off value with the ROC curves for the HALP score was 28.8. The patients were divided into two groups according to the optimal value of the HALP score (low-score group: HALP <= 28.8 [n: 134] and high-score group HALP >28.8 [n: 66]). In the group with the high HALP score, the OS was statistically longer than the low HALP score group (84 months and 53 months; p = 0.0001). In addition, when the effects of NLR, PLR, HALP score and ISS stage on OS were examined by multivariate analysis, all these markers were found to be statistically significant predictors. Conclusions HALP score may be a valuable prognostic marker for patients with multiple myeloma.
dc.identifier.citationSolmaz, Ş., Uzun, Ö., Sevindik, Ö. G., Demirkan, F., Özcan, M.A., Özsan, G. H. ... Alacacıoğlu, İ. (2023). The effect of haemoglobin, albumin, lymphocyte and platelet score on the prognosis in patients with multiple myeloma. International Journal of Laboratory Hematology, 45(1), 13-19. https://dx.doi.org/10.1111/ijlh.13958
dc.identifier.doi10.1111/ijlh.13958
dc.identifier.endpage19
dc.identifier.issn1751-5521
dc.identifier.issn1751-553X
dc.identifier.issue1
dc.identifier.pmid36053932
dc.identifier.scopus2-s2.0-85137366337
dc.identifier.scopusqualityQ2
dc.identifier.startpage13
dc.identifier.urihttps://dx.doi.org/10.1111/ijlh.13958
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10409
dc.identifier.volume45
dc.identifier.wos000848549600001en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSevindik, Ömür Gökmen
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc
dc.relation.ispartofInternational Journal of Laboratory Hematologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectHALP Score
dc.subjectMultiple Myeloma
dc.subjectOverall Survival
dc.subjectPrognosis
dc.subjectProgression-Free Survival
dc.titleThe effect of haemoglobin, albumin, lymphocyte and platelet score on the prognosis in patients with multiple myeloma
dc.typeArticle

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