The effect of BMP-2, BMP-4 and BMP-6 on bone destruction of cholesteatoma presence

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dc.contributor.authorÖger, Muzaffer
dc.contributor.authorAlpay, Hayrettin Cengiz
dc.contributor.authorOrhan, İsrafil
dc.contributor.authorÖnalan Ethem, Ebru
dc.contributor.authorYanılmaz, Muhammed
dc.contributor.authorSapmaz, Emrah
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:35:29Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:35:29Z
dc.date.issued2013
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kulak Burun Boğaz Hastalıkları Ana Bilim Dalı
dc.description.abstractThe aim of our study was to investigate the relationship between the destruction of temporal bone structures, ossicular chain destruction, dissemination of cholesteatoma and the expressions of bone morphogenetic proteins (BMPs), BMP-2, BMP-4 and BMP-6 in patients with acquired cholesteatoma. Material and Methods: This study was performed in a total of 80 patients with cholesteatoma and without cholesteatoma who had undergone surgery due to chronic otitis media. The patients were grouped as the study and the control groups. The study group comprised patients with primary acquired cholesteatoma, and the control group consisted of chronic otitis media patients without cholesteatoma. The samples were obtained from cholesteatoma tissue and the external acoustic meatus skin in study group patients and they were obtained from the external acoustic meatus skin only in control group patients. The Reverse Transcriptase Polymerase Chain Reaction method was used for the measurements of BMPs, BMP-2, BMP-4 and BMP-6 expressions. Polymerase Chain Reaction was studied by isolation of Ribonucleic Acid from the tissue samples. Results: When the expressions of BMP in the external acoustic meatus skin were compared between the study and the control groups, the BMPs, BMP-2 and BMP-6 were determined to have a statistically significant relation in the study group (p < 0.05), but BMP-4 was not significant (p > 0.05). When the expression of BMP in cholesteatoma tissue was investigated in the study group patients, the BMPs, BMP-2 and BMP-6 were determined with statistically significant positivity (p < 0.05), but there was no significant positivity for BMP-4 (p > 0.05). In the study group, there was no statistical significance between the expressions of BMPs, BMP-2, BMP-4 and BMP-6 in cholesteatoma tissue, in the external acoustic meatus skin, and temporal and ossicular chain destruction, and dissemination of cholesteatoma (p > 0.05). A statistically significant positivity for BMPs expression in cholesteatoma tissue was determined in patients with destruction of the incus + malleus + stapes (p < 0.05). Conclusion: The expressions of BMPs, BMP-2 and BMP-6, were elevated in cholesteatoma tissue. Furthermore, the positivity of BMPs expression was statistically significant in patients with destruction of all the ossicles, and we think that this marker can be used for evaluation of the aggressiveness of cholesteatoma.
dc.identifier.citationÖger, M., Alpay, H. C., Orhan, İ., Önalan Ethem, E., Yanılmaz, M. ve Sapmaz, E. (2013). The effect of BMP-2, BMP-4 and BMP-6 on bone destruction of cholesteatoma presence. American Journal of Otolaryngology - Head and Neck Medicine and Surgery, 34(6), 652-657. https://dx.doi.org/10.1016/j.amjoto.2013.06.007
dc.identifier.doi10.1016/j.amjoto.2013.06.007
dc.identifier.endpage657
dc.identifier.issn0196-0709
dc.identifier.issue6
dc.identifier.scopusqualityQ2
dc.identifier.startpage652
dc.identifier.urihttps://hdl.handle.net/20.500.12511/808
dc.identifier.urihttps://dx.doi.org/10.1016/j.amjoto.2013.06.007
dc.identifier.volume34
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.relation.ispartofAmerican Journal of Otolaryngology - Head and Neck Medicine and Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectDestruction
dc.subjectCholesteatoma
dc.subjectBone
dc.subjectBMPs
dc.subjectBMP-2
dc.subjectBMP-4
dc.subjectBMP-6
dc.titleThe effect of BMP-2, BMP-4 and BMP-6 on bone destruction of cholesteatoma presence
dc.typeArticle

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