Early onset neonatal thrombocytopenia is associated with severe intraventricular hemorrhage in very preterm infants: A retrospective cohort study

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dc.authorid0000-0001-8937-4671
dc.contributor.authorBezirganoğlu, Handan
dc.contributor.authorSarı, Fatma Nur
dc.contributor.authorÇetinkaya, A. K.
dc.contributor.authorAlyamaç Dizdar, Evrim
dc.contributor.authorBüyüktiryaki, Mehmet
dc.date.accessioned2024-01-16T11:49:15Z
dc.date.available2024-01-16T11:49:15Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractBACKGROUND: The role of platelet function in the development of intraventricular hemorrhage is still a subject of debate. In this study, we aimed to determine whether there is an association between platelet indices in the first week of life and severity of intraventricular hemorrhage in very preterm infants. MATERIALS AND METHODS: Preterm infants born < 30 weeks of gestation in our hospital were retrospectively evaluated. Platelet parameters, including platelet counts, mean platelet volume, platelet distribution width, and platelet mass were retrieved at two different time points: the initial value on the first day of life and the value closest to the end of the first week of life. The infants were categorized according to the findings of cranial ultrasonography as; no intraventricular hemorrhage, mild or severe intraventricular hemorrhage. RESULTS: Totally, 1051 infants were evaluated. The mean gestational age and birth weight for the entire cohort were 27.9 ± 1.6 weeks and 1058 ± 247 g, respectively. Infants in the severe intraventricular hemorrhage group had significantly lower gestational age (p < 0.001) and birthweight (p < 0.001) compared to other two groups. Furthermore, there were significant differences in platelet count and platelet mass between the groups at two time intervals. However, logistic regression analysis revealed that only platelet count of < 100 × 109/L on the first postnatal day was independently associated with the severity of intraventricular hemorrhage. CONCLUSION: There is an association between platelet count of < 100 × 109/L on the first postnatal day and severe intraventricular hemorrhage in very preterm infants.
dc.identifier.citationBezirganoğlu, H., Sarı, F. N., Çetinkaya, A. K., Alyamaç Dizdar, E. ve Büyüktiryaki, M. (2023). Early onset neonatal thrombocytopenia is associated with severe intraventricular hemorrhage in very preterm infants: A retrospective cohort study. Journal of Neonatal-Perinatal Medicine, 16(4), 665-671. https://dx.doi.org/10.3233/NPM-230045
dc.identifier.doi10.3233/NPM-230045
dc.identifier.endpage671
dc.identifier.issn1934-5798
dc.identifier.issn1878-4429
dc.identifier.issue4
dc.identifier.pmid37980686
dc.identifier.scopus2-s2.0-85180992533
dc.identifier.scopusqualityQ3
dc.identifier.startpage665
dc.identifier.urihttps://dx.doi.org/10.3233/NPM-230045
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12153
dc.identifier.volume16
dc.identifier.wosWOS:001276150500010
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakWeb of Science
dc.institutionauthorBüyüktiryaki, Mehmet
dc.language.isoen
dc.publisherIOS Press BV
dc.relation.ispartofJournal of Neonatal-Perinatal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMean Platelet Volume
dc.subjectNeonatal Thrombocytopenia
dc.subjectPlatelet Mass
dc.subjectPreterm
dc.titleEarly onset neonatal thrombocytopenia is associated with severe intraventricular hemorrhage in very preterm infants: A retrospective cohort study
dc.typeArticle

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