Effect of hyaluronic acid on bone formation in the expanded interpremaxillary suture in rats

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dc.contributor.authorSadıkoğlu Bekçi, Tuğba
dc.contributor.authorNalbantgil, Didem
dc.contributor.authorÜlkür, Feyza
dc.contributor.authorUlaş, Nilüfer
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:02:16Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:02:16Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.descriptionWOS: 000379974400004
dc.descriptionPubMed ID: 27132627
dc.description.abstractStructured Abstract ObjectiveTo evaluate the histomorphometric effects of different molecular weight hyaluronic acid on bone formation in rats after expansion of the interpremaxillary suture. Material and MethodsTwenty-four male Sprague Dawley rats were divided into three groups. Each group was subjected to expansion for 5 days and retention for 10 days. Group 1 received 50 l of high molecular weight hyaluronic acid (HMWHA), group 2 received 50 l of low molecular weight hyaluronic acid (LMWHA), and the control group received same amount of saline solution to the interpremaxillary suture. Ten days after injection, the rats were killed and their maxillas dissected. For the histomorphometric evaluation, blocks were serially sectioned at 10-m intervals. Sections were stained with hematoxylin-eosin (HE) and evaluated with image analysis software. Bone area (m(2)) (BA), bone perimeter of suture borders (m) (BP), and ratio of osteoblast cells and capillary cells to BA and BP parameters were evaluated. ResultsHMWHA showed a statistically higher ratio of osteoblast and capillary cell scores compared with the LMWHA and control groups (p < 0.05). There were no statistically significant differences in between LMWHA and control groups (p > 0.05). ConclusionsLocal injection of HMWHA in the interpremaxillary suture after rapid maxillary expansion stimulated new bone formation, which may shorten the retention period and may reduce the risk of relapse. LMWHA has no effect on bone formation in interpremaxillary suture.
dc.description.sponsorshipMedipol University Department of Histologyen_US
dc.description.sponsorshipHistomorphometric and Histopathological evaluation was supported by Medipol University Department of Histology. We appreciate Assist. Prof. Cigdem Kaspar's for help on statistical analysis.en_US
dc.identifier.citationSadıkoğlu Bekçi, T., Nalbantgil, D., Ülkür, F. ve Ulaş, N. (2016). Effect of hyaluronic acid on bone formation in the expanded interpremaxillary suture in rats. Orthodontics & Craniofacial Research, 19(3), 154-161. https://dx.doi.org/10.1111/ocr.12123
dc.identifier.doi10.1111/ocr.12123
dc.identifier.endpage161
dc.identifier.issn1601-6335
dc.identifier.issn1601-6343
dc.identifier.issue3
dc.identifier.scopusqualityQ1
dc.identifier.startpage154
dc.identifier.urihttps://dx.doi.org/10.1111/ocr.12123
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3600
dc.identifier.volume19
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley Blackwell
dc.relation.ispartofOrthodontics & Craniofacial Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectHistomorphometry
dc.subjectHyaluronic Acid
dc.subjectMaxillary Expansion
dc.subjectOrthodontics
dc.subjectRat
dc.titleEffect of hyaluronic acid on bone formation in the expanded interpremaxillary suture in rats
dc.typeArticle

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