Genomic analysis reveals the biotechnological and industrial potential of levan producing halophilic extremophile, Halomonas smyrnensis AAD6T

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dc.authorid0000-0002-0060-2859
dc.contributor.authorDiken, Elif
dc.contributor.authorÖzer, Tuğba
dc.contributor.authorArıkan, Muzaffer
dc.contributor.authorEmrence, Zeliha
dc.contributor.authorToksoy Öner, Ebru
dc.contributor.authorÜstek, Duran
dc.contributor.authorArğa, Kazım Yalçın
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:03:07Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:03:07Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Genetik Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.descriptionWOS: 000359435700004
dc.descriptionPubMed ID: 26251777
dc.description.abstractHalomonas smyrnensis AAD6T is a gram negative, aerobic, and moderately halophilic bacterium, and is known to produce high levels of levan with many potential uses in foods, feeds, cosmetics, pharmaceutical and chemical industries due to its outstanding properties. Here, the whole-genome analysis was performed to gain more insight about the biological mechanisms, and the whole-genome organization of the bacterium. Industrially crucial genes, including the levansucrase, were detected and the genome-scale metabolic model of H. smyrnensis AAD6T was reconstructed. The bacterium was found to have many potential applications in biotechnology not only being a levan producer, but also because of its capacity to produce Pel exopolysaccharide, polyhydroxyalkanoates, and osmoprotectants. The genomic information presented here will not only provide additional information to enhance our understanding of the genetic and metabolic network of halophilic bacteria, but also accelerate the research on systematical design of engineering strategies for biotechnology applications.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [MAG/110M613]; Marmara University Research Fund [FEN-C-YLP-060911-0280]en_US
dc.description.sponsorshipThis research has been financially supported by The Scientific and Technological Research Council of Turkey (TUBITAK) through Grant MAG/110M613 and by Marmara University Research Fund through Grant FEN-C-YLP-060911-0280.en_US
dc.identifier.citationDiken, E., Özer, T., Arıkan, M., Emrence, Z., Toksoy Öner, E., Üstek, D. ve Arğa, K. Y. (2015). Genomic analysis reveals the biotechnological and industrial potential of levan producing halophilic extremophile, Halomonas smyrnensis AAD6T. SpringerPlus, 4. https://dx.doi.org/10.1186/s40064-015-1184-3
dc.identifier.doi10.1186/s40064-015-1184-3
dc.identifier.issn2193-1801
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://dx.doi.org/10.1186/s40064-015-1184-3
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3808
dc.identifier.volume4
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer International Publishing
dc.relation.ecinfo:eu repo/grantAgreement/TUBITAK/SOBAG/MAG/110M613
dc.relation.ispartofSpringerPlusen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectHalomonas Smyrnensis
dc.subjectHalophiles
dc.subjectGenome
dc.subjectNext-Generation sequencing
dc.subjectLevan
dc.titleGenomic analysis reveals the biotechnological and industrial potential of levan producing halophilic extremophile, Halomonas smyrnensis AAD6T
dc.typeArticle

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