Is vagal stimulation or inhibition benefit on the regulation of the stomach brain axis in obesity?

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dc.authorid0000-0002-6984-3079
dc.contributor.authorAlkan, Işınsu
dc.contributor.authorAltunkaynak, Berrin Zuhal
dc.contributor.authorKıvrak, Elfide Gizem
dc.contributor.authorKaplan, Arife Ahsen
dc.contributor.authorArslan, Gülay
dc.date.accessioned2023-01-02T12:58:49Z
dc.date.available2023-01-02T12:58:49Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractObjective:Possible effects of the vagus inhibition and stimulation on the hypothalamic nuclei, myenteric plexes and the vagus nerve were investigated. Methods:The female rats divided to the inhibition (INH), stimulation (STI) and, sham (SHAM) groups were fed with high fat diet (including 40% of energy from animal fat). After nine weeks, the rats were allowed to recover for 4 weeks in INH group. In STI group, the left vagus nerve stimulated (30 Hz/500 msn/30 sec.) starting 2nd post operative day for 5 minutes during 4 weeks. Healthy female rats used as control (CONT). Then, tissue samples were analyzed by biochemical, histological and stereological methods. Results:The mean number of the neurons in the arcuate nucleus of the INH group was significantly less; but, that is significantly more in the STI group compared to the other groups. The neuronal density of ventromedial nucleus in the STI group was higher; while the density in the INH group was lower than the other groups. In the dorsomedial nucleus, neuron density of the INH group was lower than the other groups. In terms of the myenteric plexus volumes, that of the INH group was lowest. The myelinated axon number in the INH group was significantly highest. The myelin sheath thickness and axon area of the INH group was significantly lower than the other groups. Discussion:The results of the study show that the vagal inhibition is more effective than the vagal stimulation on the weight loss in the obesity.
dc.identifier.citationAlkan, I., Altunkaynak, B. Z., Kıvrak, E. G., Kaplan, A. A. ve Arslan, G. (2022). Is vagal stimulation or inhibition benefit on the regulation of the stomach brain axis in obesity? Nutritional Neuroscience, 25(4), 758-770. https://doi.org/10.1080/1028415X.2020.1809875
dc.identifier.doi10.1080/1028415X.2020.1809875
dc.identifier.endpage770
dc.identifier.issn1028-415X
dc.identifier.issn1476-8305
dc.identifier.issue4
dc.identifier.pmid33034260
dc.identifier.scopus2-s2.0-85092362384
dc.identifier.scopusqualityQ2
dc.identifier.startpage758
dc.identifier.urihttps://doi.org/10.1080/1028415X.2020.1809875
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10227
dc.identifier.volume25
dc.identifier.wos000578918400001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKaplan, Arife Ahsen
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofNutritional Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/214S614
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectHypothalamic Nuclei
dc.subjectMyenteric Plexus
dc.subjectNPY
dc.subjectObesity
dc.subjectPOMC
dc.subjectVagal Inhibition
dc.subjectVagal Stimulation
dc.titleIs vagal stimulation or inhibition benefit on the regulation of the stomach brain axis in obesity?
dc.typeArticle

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