Efficacy of statins on sirtuin 1 and endothelial nitric oxide synthase expression: The role of sirtuin 1 gene variants in human coronary atherosclerosis

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dc.authorid0000-0002-6895-8560
dc.contributor.authorKılıç, Ülkan
dc.contributor.authorGök, Özlem
dc.contributor.authorElibol, Birsen
dc.contributor.authorUysal, Ömer
dc.contributor.authorBacaksız, Ahmet
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:51:14Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:51:14Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.descriptionWOS: 000351832200002
dc.descriptionPubMed ID: 25582759
dc.description.abstractStatins are 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors and are used to reduce the risk of coronary artery disease (CAD) due to their pleiotropic effects. Recently, greater focus has been placed on the role of sirtuin 1 (SIRT1) in cardiovascular disease research. However, insufficient data exist on the relationships between statins, SIRT1 protein levels, and SIRT1 gene variants. In the present study, we investigated the effects of statins, atorvastatin and rosuvastatin, in CAD patients by analysing the associations between SIRT1 gene variants, rs7069102C>G and rs2273773C>T, and SIRT1/endothelial nitric oxide (eNOS) expression, as well as total antioxidant and oxidant status, and the oxidative stress index. SIRT1 expression was significantly higher, and eNOS expression was significantly lower in CAD patients when compared with controls. Statin treatment reduced SIRT1 expression and increased eNOS expression, similar to the levels found in the control population, independent from the studied SIRT1 gene variants. Oxidative stress parameters were significantly increased in CAD patients, and were decreased by statin treatment, demonstrating the antioxidative effects of statins on atherosclerosis. These results indicate that statin treatment could produce its protective effect on cardiovascular disease through the inhibition of SIRT1 expression. This is the first study reporting on the effect of statins, specifically atorvastatin and rosuvastatin, on SIRT1 expression in CAD patients.
dc.identifier.citationKılıç, Ü., Gök, Ö., Elibol, B., Uysal, Ö. ve Bacaksız, A. (2015). Efficacy of statins on sirtuin 1 and endothelial nitric oxide synthase expression: The role of sirtuin 1 gene variants in human coronary atherosclerosis. Clinical and Experimental Pharmacology and Physiology, 42(4), 321-330. https://dx.doi.org/10.1111/1440-1681.12362
dc.identifier.doi10.1111/1440-1681.12362
dc.identifier.endpage330
dc.identifier.issn0305-1870
dc.identifier.issn1440-1681
dc.identifier.issue4
dc.identifier.scopusqualityQ2
dc.identifier.startpage321
dc.identifier.urihttps://dx.doi.org/10.1111/1440-1681.12362
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2177
dc.identifier.volume42
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofClinical and Experimental Pharmacology and Physiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectCoronary Artery Disease
dc.subjectEndothelial Nitric Oxide
dc.subjectOxidative Stress
dc.subjectSirtuin 1 Gene Variant
dc.subjectStatin
dc.titleEfficacy of statins on sirtuin 1 and endothelial nitric oxide synthase expression: The role of sirtuin 1 gene variants in human coronary atherosclerosis
dc.typeArticle

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