The efficiency of ozone therapy and low-level laser therapy in rat facial nerve injury

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dc.authorid0000-0002-4899-9146
dc.contributor.authorYuca, Yusuf
dc.contributor.authorYücesoy, Türker
dc.contributor.authorTok, Olgu Enis
dc.contributor.authorAlkan, Alper
dc.date.accessioned2020-04-14T10:24:49Z
dc.date.available2020-04-14T10:24:49Z
dc.date.issued2020
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractPurpose: Comparison of low-level laser therapy (LLLT) and ozone therapy (OT) methods for the treatment of facial nerve injury (FNI) in rats, evaluated by histomorphometric measurement analysis. Materials and methods: Thirty rats were randomly divided into control (C), LLLT, and OT groups. The left facial nerves (FNs) of all rats (n ¼ 30) were used in this study. These were held in a surgical clamp for 30 s to create neuropathic damage. The non-injured right FNs of the rats in the control group formed the fourth, sham (S) group in this study (n ¼ 10). Therefore the total number of evaluated samples was 40. The injured FNs of rats in the control group were left to heal spontaneously, whereas LLLT was applied for 21 consecutive days (output 100 mW/cm2 and wavelength 850 nm) and OT (2 ml; 80 mm/ml) once every 2 days for 21 days. Results: After histomorphological evaluation, the OT group revealed statistically significant outcomes following FNI compared with the OT and control groups in terms of branching of nerve fibers (p ¼ 0.003), nerve fiber diameters (p ¼ 0.0398), nerve fiber areas (p ¼ 0.042), and axon numbers (p ¼ 0.0327). Although the LLLT group revealed a better healing process than the control group, the outcome was not statistically significant in terms of branching of nerve fibers (p ¼ 0.6804), nerve fiber diameters (p ¼ 0.7424), nerve fiber areas (p ¼ 0.7048), and axon numbers (p ¼ 0.7588). Conclusions: OT resulted in statistically significant differences in outcome when compared with the LLLT and control groups, and provided a safe and effective treatment for FNI in rats. OT could therefore be considered as an alternative treatment of FNI. Clinical studies should now be performed to establish whether comparable results can be achieved in humans.
dc.identifier.citationYüca, Y., Yücesoy, T., Tok, O. E. ve Alkan, A. (2020). The efficiency of ozone therapy and low-level laser therapy in rat facial nerve injury. Journal of Cranio-Maxillofacial Surgery, 48(3), 308-314. https://dx.doi.org/10.1016/j.jcms.2020.01.017
dc.identifier.doi10.1016/j.jcms.2020.01.017
dc.identifier.endpage314
dc.identifier.issn1010-5182
dc.identifier.issn1878-4119
dc.identifier.issue3
dc.identifier.scopusqualityN/A
dc.identifier.startpage308
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5115
dc.identifier.urihttps://dx.doi.org/10.1016/j.jcms.2020.01.017
dc.identifier.volume48
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherChurchill Livingstone
dc.relation.ispartofJournal of Cranio-Maxillofacial Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectFacial Nerve Injury
dc.subjectLow-Level Laser Therapy
dc.subjectOzone
dc.subjectPeripheral Nerve Injury
dc.titleThe efficiency of ozone therapy and low-level laser therapy in rat facial nerve injury
dc.typeArticle

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