Relationship between histopathological findings of patients with dermatochalasis and vitamin D deficiency

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dc.authorid0000-0003-1827-968X
dc.contributor.authorAydemir, Emre
dc.contributor.authorMalkoç Şen, Emine
dc.contributor.authorAksoy Aydemir, Gözde
dc.contributor.authorBayat, Alper Halil
dc.contributor.authorKarnaz, Ali
dc.contributor.authorAydın Türk, Bilge
dc.date.accessioned2024-07-05T08:36:19Z
dc.date.available2024-07-05T08:36:19Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalı
dc.description.abstractPurpose: To compare the histopathological findings of patients who had been diagnosed with dermatochalasis (DC) and had undergone upper eyelid blepharoplasty (ULB) as well as those of controls (C-Group) according to their serum vitamin D (SVD) levels. Methods: The prospective study included 136 upper eyelid skin from 68 patients who underwent surgery for DC and 53 upper eyelid skin from 53 patients who underwent levator surgery with ULB. The DC Group was then divided into 3 subgroups according to the marginal reflex distance (MRD4). The lymphatic vessel (LV) count and diameter of the largest LV (DLLV) were recorded, the stromal collagen bed (SCB) was observed, and its depth was measured, the interfibrillar edema was examined, and the elastic fiber and macrophage counts and recorded, respectively, and then all of these were evaluated. The SVD levels were compared between the DC patients and the C-Group. Results: In comparison to the C-Group, significant changes were seen in the dilated LV, DLLV, SCB depth, interfibrillar edema, elastic fiber density, and macrophage count in the DC sub-Groups (P < 0.001 for all). While no difference was found between DC sub-Group 1 (MRD4 > 4 mm) and the C-Group (P > 0.05), a significant difference was found between DC sub-Group 2 (MRD4 2-4 mm) and DC sub-Group 3 (MRD4 < 2 mm) for all of the parameters (P < 0.05). A statistically significant difference was also found in the SVD levels between the DC sub-Group 1 and DC sub-Groups 2-3 (P < 0.017, P < 0.001 respectively). Conclusion: According to the results of this study, SVD level was significantly lower in DC group. Moreover, an increased LV count and diameter, decreased elastic fiber count, collagen fiber and stromal edema irregularity, and increased macrophage count were found to be associated with the SVD level.
dc.identifier.citationAydemir, E., Malkoç Şen, E., Aksoy Aydemir, G., Bayat, A. H., Karnaz, A. ve Aydın Türk, B. (2024). Relationship between histopathological findings of patients with dermatochalasis and vitamin D deficiency. International Ophthalmology, 44(1). http://dx.doi.org/10.1007/s10792-024-03209-3
dc.identifier.doi10.1007/s10792-024-03209-3
dc.identifier.issn0165-5701
dc.identifier.issn1573-2630
dc.identifier.issue1
dc.identifier.pmid38960909
dc.identifier.scopus2-s2.0-85197676481
dc.identifier.scopusqualityQ2
dc.identifier.urihttp://dx.doi.org/10.1007/s10792-024-03209-3
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12702
dc.identifier.volume44
dc.identifier.wos001262570100002en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBayat, Alper Halil
dc.language.isoen
dc.relation.ispartofInternational Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCollagen
dc.subjectDermatochalasis
dc.subjectElastic Fiber
dc.subjectHistopathology
dc.subjectSerum Vitamin D
dc.subjectVitamin D Deficiency
dc.titleRelationship between histopathological findings of patients with dermatochalasis and vitamin D deficiency
dc.typeArticle

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