Cytokine gene polymorphism frequencies in Turkish population living in Marmara region

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dc.authorid0000-0002-7129-5024
dc.contributor.authorÖzdilli, Kürşat
dc.contributor.authorDuvarcı Öğret, Yeliz
dc.contributor.authorOğuz, Süleyman Rüştü
dc.contributor.authorAbatay Sel, Figen
dc.contributor.authorŞentürk Çiftçi, Hayriye
dc.contributor.authorKekik Çınar, Çiğdem
dc.contributor.authorPehlivan, Sacide
dc.contributor.authorSavran Oğuz, Fatma
dc.date.accessioned2022-11-16T12:06:59Z
dc.date.available2022-11-16T12:06:59Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.description.abstractObjectives Sequence variants in cytokine genes are related to affect cytokine gene levels. In this study, it was aimed to examine eight single nucleotide polymorphisms (SNPs) in five cytokine genes (TNF-alpha, INF-gamma, IL-6, IL10, TGF-beta) for the Turkish population living in Marmara region and to reveal the genetic distance between the study group and other populations. Methods In this study, three-hundred unrelated healthy individuals were involved and all genotyping were performed by using sequence-specific primers PCR (PCR-SSP) method. The SNP data were analyzed for Hardy Weinberg equilibrium fit by calculating expected genotype frequencies and comparing them to the observed values using Arlequin software version 3.1. The genetic distances between the study group and other populations were calculated and a neighbor-joining tree was constructed by PHYLIP. Results The observed genotypes of TNF-alpha (-308), IFN-gamma (+874), TGF-beta (codon 10), and TGF-beta (codon 25) of the subjects were found to be similar with other populations investigated in this study. However, there is a significant frequency difference for IL-6 and IL-10 genotypes between populations. Conclusions The current population study provided more reference values for these polymorphisms and generated a control group to be used in further association studies especially for transplantation, GVHD, autoimmune and malign disease.
dc.identifier.citationÖzdilli, K., Duvarcı Öğret, Y., Oğuz, S. R., Abatay Sel, F., Şentürk Çiftçi, H., Kekik Çınar, Ç. ... Savran Oğuz, F. (2022). Cytokine gene polymorphism frequencies in Turkish population living in Marmara region. Turkish Journal of Biochemistry, 47(5), 580-587. https://doi.org/10.1515/tjb-2021-0260
dc.identifier.doi10.1515/tjb-2021-0260
dc.identifier.endpage587
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue5
dc.identifier.scopus2-s2.0-85130922159
dc.identifier.scopusqualityQ4
dc.identifier.startpage580
dc.identifier.urihttps://doi.org/10.1515/tjb-2021-0260
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9978
dc.identifier.volume47
dc.identifier.wos000799156800001en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorÖzdilli, Kürşat
dc.language.isoen
dc.publisherDe Gruyter Open Ltd
dc.relation.ispartofTurkish Journal of Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectCytokine
dc.subjectDisease
dc.subjectGenetics
dc.subjectPopulation
dc.subjectSingle Nucleotide Polymorphism
dc.titleCytokine gene polymorphism frequencies in Turkish population living in Marmara region
dc.typeArticle

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