Comparison of liquid-based cytology and cell blocks prepared from cell remnants for diagnosis of cervical pathology

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dc.authorid0000-0002-0600-5801
dc.authorid0000-0002-2901-4671
dc.authorid0000-0001-6080-0673
dc.contributor.authorKuzucular, Elif
dc.contributor.authorÖzden, Ferhat
dc.contributor.authorMüezzinoğlu, Bahar
dc.date.accessioned2024-02-02T09:13:25Z
dc.date.available2024-02-02T09:13:25Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.description.abstractBackground: Cervical cancer is a global public health problem with high mortality. Advances in screening programs for cervical cancer are considered key to eliminate cervical cancer. We aimed to examine the contribution of cell block analysis to the detection of epithelial cell abnormalities in cervical smear samples. Methods: A total of 559 patients with suspected cervical pathology were examined, and their samples were analyzed by both liquid-based cytology (LBC) and cell blocks. The biopsy results of 149 out of the 559 patients were obtained. Results: Of the 50 patients who were identified as HSIL by biopsy, only 12 were diagnosed as HSIL by the LBC method, 22 as LSIL, 12 as ASCUS, and 4 as ASC-H (p < 0.001). With the cell block analysis, results for these patients were: 20 HSIL, 17 LSIL, 7 NILM, 4 ‘unsatisfactory’, and 2 ASC cases (p < 0.001). LBC detected only 1 of the 10 patients with biopsy-diagnosed tumors, while 7 of these were defined as HSIL, 1 as ASCUS and 1 as AGC. The results of cell block analysis in patients with biopsy-diagnosed tumors were as follows: 7 HSIL, 1 tumor, 1 ASC and 1 LSIL. Conclusions: Cell block analysis might be superior to LBC in terms of diagnostic accuracy in cervical pathologies, particularly in the detection of HSIL. However, both methods were similarly poor in diagnosing tumors. Cell blocks may improve diagnostic accuracy and can be a complementary method to LBC, while having the advantage of revealing histological architecture.
dc.identifier.citationKuzucular, E., Özden, F. ve Müezzinoğlu, B. (2024). Comparison of liquid-based cytology and cell blocks prepared from cell remnants for diagnosis of cervical pathology. Annals of Diagnostic Pathology, 69. https://dx.doi.org/10.1016/j.anndiagpath.2024.152265
dc.identifier.doi10.1016/j.anndiagpath.2024.152265
dc.identifier.issn1092-9134
dc.identifier.issn1532-8198
dc.identifier.pmid38266543
dc.identifier.scopus2-s2.0-85183161510
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://dx.doi.org/10.1016/j.anndiagpath.2024.152265
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12242
dc.identifier.volume69
dc.identifier.wos001171369000001*
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKuzucular, Elif
dc.institutionauthorÖzden, Ferhat
dc.institutionauthorMüezzinoğlu, Bahar
dc.language.isoen
dc.publisherW.B. Saunders
dc.relation.ispartofAnnals of Diagnostic Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectCell Block
dc.subjectCervical Cancer
dc.subjectHSIL
dc.subjectLiquid-Based Cytology
dc.subjectPap Smear
dc.titleComparison of liquid-based cytology and cell blocks prepared from cell remnants for diagnosis of cervical pathology
dc.typeArticle

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