Prognostic importance of single-nucleotide polymorphisms in IL-6, IL-10, TGF-beta 1, IFN-gamma, and TNF-alpha genes in chronic phase chronic myeloid leukemia

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dc.authorid0000-0002-7129-5024
dc.contributor.authorPehlivan, Mustafa
dc.contributor.authorHaydaroğlu Şahin, Handan
dc.contributor.authorPehlivan, Sacide
dc.contributor.authorÖzdilli, Kürşat
dc.contributor.authorKaynar, Leylagül
dc.contributor.authorSavran Oğuz, Fatma
dc.contributor.authorSever, Tuğçe
dc.contributor.authorYılmaz, Mehmet
dc.contributor.authorEser, Bülent
dc.contributor.authorDuvarcı Öğret, Yeliz
dc.contributor.authorKis, Cem
dc.contributor.authorOkan, Vahap
dc.contributor.authorÇetin, Mustafa
dc.contributor.authorCarin, Mahmut
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:05Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:05Z
dc.date.issued2014
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000337183000006
dc.descriptionPubMed ID: 24819026
dc.description.abstractThe aim of this study was to explore the association between polymorphisms of five cytokine genes and clinical parameters in patients with Philadelphia-positive (Ph+) chronic myeloid leukemia (CML) treated with imatinib. We analyzed five cytokine genes (interleukin [IL]-6, IL-10, gamma interferon [IFN-gamma], transforming growth factor beta-1 [TGF-beta 1], and tumor necrosis factor-alpha [TNF-alpha]) in 60 cases with Ph+ CML and 74 healthy controls. Cytokine genotyping was performed by the polymerase chain reaction-sequence-specific primer. All data were analyzed using the de Finetti program and SPSS version 14.0 for Windows. No significant differences were detected between the CML group and healthy controls with respect to the distributions and numbers of genotypes and alleles in TNF-alpha, TGF-beta 1, IL-10, and IFN-gamma. However, the GG genotype associated with high expression in IL-6 was found to be significantly more frequent in CML as compared to controls (p = 0.010). The median follow-up time was 49.3 months (range 6.1-168.4) and the median duration of imatinib treatment was 39.5 months (range 5.2-103.4) for these patients. On multivariateanalysis, only IL-10 GCC/GCC highly produced haplotypes were significantly associated with a shorter event-free survival. The relationship between cytokine genotypes/haplotypes and clinical parameters in CML has not been investigated before. Our results suggest that IL-10 may be a useful marker for CML prognosis and theGG genotype of the IL-6 gene may be associated with susceptibility.
dc.identifier.citationPehlivan, M., Haydaroğlu Şahin, H., Pehlivan, S., Özdilli, K., Kaynar, L., Savran Oğuz, F. ... Carin, M. (2014). Prognostic importance of single-nucleotide polymorphisms in IL-6, IL-10, TGF-beta 1, IFN-gamma, and TNF-alpha genes in chronic phase chronic myeloid leukemia. Genetic Testing and Molecular Biomarkers, 18(6), 403-409. https://dx.doi.org/10.1089/gtmb.2014.0011
dc.identifier.doi10.1089/gtmb.2014.0011
dc.identifier.endpage409
dc.identifier.issn1945-0265
dc.identifier.issn1945-0257
dc.identifier.issue6
dc.identifier.scopusqualityQ2
dc.identifier.startpage403
dc.identifier.urihttps://dx.doi.org/10.1089/gtmb.2014.0011
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2566
dc.identifier.volume18
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMary Ann Liebert, Inc
dc.relation.ispartofGenetic Testing and Molecular Biomarkersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPrognostic Importance
dc.subjectSingle-Nucleotide Polymorphisms
dc.subjectIL-6
dc.subjectIL-10
dc.subjectTGF-b1
dc.subjectIFN-g
dc.subjectTNF-a
dc.subjectChronic Phase
dc.subjectChronic Myeloid Leukemia
dc.titlePrognostic importance of single-nucleotide polymorphisms in IL-6, IL-10, TGF-beta 1, IFN-gamma, and TNF-alpha genes in chronic phase chronic myeloid leukemia
dc.typeArticle

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