CD4+CD25+CD127loFOXP3+ cell in food allergy: Does it predict anaphylaxis?
| dc.authorid | 0000-0003-1333-2648 | |
| dc.contributor.author | Bahçeci Erdem, Semiha | |
| dc.contributor.author | Genel, Ferah | |
| dc.contributor.author | Nacaroğlu, Hikmet Tekin | |
| dc.contributor.author | Karaman, Sait | |
| dc.contributor.author | Ünsal Karkıner, Canan Şule | |
| dc.contributor.author | Sürücü, Murat | |
| dc.contributor.author | Can, Demet | |
| dc.date.accessioned | 2023-05-30T08:22:03Z | |
| dc.date.available | 2023-05-30T08:22:03Z | |
| dc.date.issued | 2023 | |
| dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı | |
| dc.description.abstract | Background: Food allergy (FA), hence the incidence of food anaphylaxis, is a public health problem that has increased in recent years. There are still no biomarkers for patients with FA to predict severe allergic reactions such as anaphylaxis. Objective: There is limited information on whether regulatory T (Treg) cell levels are a biomarker that predicts clinical severity in cases presenting with FA, and which patients are at a greater risk for anaphylaxis. Methods: A total of 70 children were included in the study: 25 who had IgE-mediated cow’s milk protein allergy (CMPA) and presented with non-anaphylactic symptoms (FA/A?), 16 who had IgE-mediated CMPA and presented with anaphylaxis (FA/A+) (a total of 41 FA cases), and a control group consisting of 29 children without FA. The study was conducted by performing CD4+CD25+CD127loFOXP3+ cell flow cytometric analysis during resting at least 2 weeks after the elimination diet to FA subjects. Results: When the FA group was compared with healthy control subjects, CD4+CD25+CD127loFOXP3+ cell rates were found to be significantly lower in the FA group (p < 0.001). When the FA/A? and FA/A+ groups and the control group were compared in terms of CD4+CD25+CD127loFOXP3+ cell ratios, they were significantly lower in the FA/A? and FA/A+ groups compared to the control group (p < 0.001). Conclusions: Although there was no significant difference between the FA/A+ group and the FA/ A? group in terms of CD4+CD25+CD127loFOXP3+ cells, our study is important, as it is the first pediatric study we know to investigate whether CD4+CD25+CD127loFOXP3+cells in FA p redict anaphylaxis. | |
| dc.identifier.citation | Bahçeci Erdem, S., Genel, F., Nacaroğlu, H. T., Karaman, S., Ünsal Karkıner, C. Ş., Sürücü, M. ... Can, D. (2023). CD4+CD25+CD127loFOXP3+ cell in food allergy: Does it predict anaphylaxis? Allergologia et Immunopathologia, 51(3), 8-14. https://doi.org/10.15586/aei.v51i3.797 | |
| dc.identifier.doi | 10.15586/aei.v51i3.797 | |
| dc.identifier.endpage | 14 | |
| dc.identifier.issn | 0301-0546 | |
| dc.identifier.issn | 1578-1267 | |
| dc.identifier.issue | 3 | |
| dc.identifier.pmid | 37169554 | |
| dc.identifier.scopus | 2-s2.0-85158915325 | |
| dc.identifier.scopusquality | Q3 | |
| dc.identifier.startpage | 8 | |
| dc.identifier.uri | https://doi.org/10.15586/aei.v51i3.797 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12511/10994 | |
| dc.identifier.volume | 51 | |
| dc.identifier.wos | 001036844100002 | en_US |
| dc.identifier.wosquality | Q4 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | PubMed | |
| dc.institutionauthor | Nacaroğlu, Hikmet Tekin | |
| dc.language.iso | en | |
| dc.publisher | Codon Publications | |
| dc.relation.ispartof | Allergologia et Immunopathologia | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | Anaphylaxis | |
| dc.subject | Children | |
| dc.subject | Cow’s Milk Protein Allergy | |
| dc.subject | Food Allergy | |
| dc.subject | FOXP3 | |
| dc.subject | Treg Cells | |
| dc.title | CD4+CD25+CD127loFOXP3+ cell in food allergy: Does it predict anaphylaxis? | |
| dc.type | Article |
