Dry eye assessment in patients with vitiligo

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dc.authorid0000-0001-9829-7268
dc.authorid0000-0003-0668-3749
dc.authorid0000-0001-5057-0405
dc.authorid0000-0001-8954-5055
dc.authorid0000-0001-5335-3860
dc.contributor.authorKaraman Erdur, Sevil
dc.contributor.authorAydın, Rukiye
dc.contributor.authorBalevi, Ali
dc.contributor.authorÖzsütçü, Mustafa
dc.contributor.authorKocabora, Mehmet Selim
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:51:35Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:51:35Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Deri ve Zührevi Hastalıklar Ana Bilim Dalı
dc.descriptionWOS: 000429590300011
dc.descriptionPubMed ID: 29300260
dc.description.abstractPurpose:To evaluate tear osmolarity and tear film parameters in patients with vitiligo.Methods:A total of 25 eyes of 25 patients with vitiligo with periocular involvement (group 1), 30 eyes of 30 patients with vitiligo without periocular involvement (group 2), and 20 eyes of 20 controls (group 3) were evaluated using the Ocular Surface Disease Index (OSDI) questionnaire, Schirmer I test, tear film breakup time, scoring of ocular surface fluorescein staining using a modified Oxford scale, and tear osmolarity.Results:Mean tear osmolarity was 332 16.3 mOsm/L in group 1, 308.8 +/- 19.5 mOsm/L in group 2, and 286.3 +/- 23.4 mOsm/L in group 3 (P < 0.001). There was no significant difference in Schirmer I test results among the 3 groups (16.5 +/- 3.2 mm in group 1, 16.3 +/- 4.7 mm in group 2, and 17.4 +/- 4.2 mm in group 3) (P = 0.175). Tear film breakup time measurements in groups 1 (9.8 +/- 3.5 seconds) and 2 (10.1 +/- 4.3 seconds) were significantly lower than those in group 3 (18.5 +/- 4.0 seconds) (P <0.001). There was no significant difference among the 3 groups on the Oxford scale (0.04 +/- 0.70 in group 1, 0.03 +/- 0.33 in group 2, and 0.03 +/- 0.20 in group 3) (P = 0.865). The mean Ocular Surface Disease Index score was significantly higher in groups 1 and 2 than in group 3 (42.1 +/- 16.5 in group 1, 39.9 +/- 17.3 in group 2, and 12.3 +/- 11.6 in group 3) (P <0.001). Conclusions:This study showed that vitiligo is associated with tear hyperosmolarity and tear film dysfunction. Patients with vitiligo with periocular involvement may be more prone to dry eye than those without ocular involvement.
dc.identifier.citationKaraman Erdur, S., Aydın, R., Balevi, A., Özsütçü, M. ve Kocabora, M. S. (2018). Dry eye assessment in patients with vitiligo. Cornea, 37(4), 412-415.
dc.identifier.endpage415
dc.identifier.issn0277-3740
dc.identifier.issn1536-4798
dc.identifier.issue4
dc.identifier.scopusqualityQ1
dc.identifier.startpage412
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2245
dc.identifier.volume37
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofCorneaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectDry Eye
dc.subjectOcular Surface
dc.subjectMeibomian Gland Dysfunction
dc.subjectTear Osmolarity
dc.subjectVitiligo
dc.subjectPeriocular
dc.titleDry eye assessment in patients with vitiligo
dc.typeArticle

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