The effect of resveratrol on sphingosine-1 and oxidative/ nitrosative stress in an experimental heart ischemia reperfusion model

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dc.authorid0000-0002-2306-5937
dc.contributor.authorAvnioğlu, Seda
dc.contributor.authorGüngör, Meltem
dc.contributor.authorKurutaş, Ergül
dc.contributor.authorÖztürk, Ünal
dc.contributor.authorDemirhan, İlter
dc.contributor.authorBakariş, Sevgi
dc.contributor.authorVelioğlu, Halil Aziz
dc.contributor.authorÇankaya, Şeyda
dc.contributor.authorYuluğ, Burak
dc.date.accessioned2022-03-03T09:04:12Z
dc.date.available2022-03-03T09:04:12Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.description.abstractObjectives: Resveratrol (RSV) is a natural polyphenolic compound showing significant antioxidant effects. In this study, we aimed to investigate the effects of resveratrol on the sphingosine-1-phosphate (S1P) and oxidative stress biomarkers in hearth ischemia-reperfusion (I/R). Materials and Methods: The biochemical and histopathological effects of RSV on cardiac ischemia-reperfusion injury were investigated through ELISA- and light microscope. Results: We observed statistically significant differences between the treatment group and the control group in terms of malondialdehyde (MDA) level, catalase (CAT) and superoxide dismutase (SOD) activities (p<0.05). Histopathologically, we also observed decreased Polymorphonuclear Leucocyte (PMNL) infiltration, myocardial edema, miyositolysis in the treatment group compared to the I/R and sham groups. Conclusion: Resveratrol may play an important role in cardiac I/R injury through its anti-inflammatory and antioxidant effects which were biochemically and histopathologically confirmed in the present study.
dc.identifier.citationAvnioğlu, S., Güngör, M., Kurutaş, E., Öztürk, Ü., Demirhan, İ., Bakariş, S. ... Yuluğ, B. (2022). The effect of resveratrol on sphingosine-1 and oxidative/ nitrosative stress in an experimental heart ischemia reperfusion model. Revista Romana de Medicina de Laborator, 30(1), 9-18. https://doi.org/10.2478/rrlm-2021-0036
dc.identifier.doi10.2478/rrlm-2021-0036
dc.identifier.endpage18
dc.identifier.issn1841-6624
dc.identifier.issn2284-5623
dc.identifier.issue1
dc.identifier.startpage9
dc.identifier.urihttps://doi.org/10.2478/rrlm-2021-0036
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9085
dc.identifier.volume30
dc.identifier.wos000754348900001en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.institutionauthorVelioğlu, Halil Aziz
dc.language.isoen
dc.publisherUniversity Press
dc.relation.ispartofRevista Romana de Medicina de Laboratoren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectResveratrol
dc.subjectIschemia/Reperfusion Injury
dc.subjectAntioxidant
dc.subjectOxidative Stress
dc.subjectHeart
dc.titleThe effect of resveratrol on sphingosine-1 and oxidative/ nitrosative stress in an experimental heart ischemia reperfusion model
dc.typeArticle

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