Sex differences in clinical and polysomnographic features of obstructive sleep apnea: The Turkish sleep apnea database (TURKAPNE) cohort

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dc.contributor.authorPıhtılı, Aylin
dc.contributor.authorKıyan, Esen
dc.contributor.authorBalcan, Baran
dc.contributor.authorArbatlı, Semih
dc.contributor.authorÇilli, Aykut
dc.contributor.authorAltıntaş, Nejat
dc.contributor.authorAkkoyunlu, Muhammed Emin
dc.date.accessioned2025-12-11T11:07:20Z
dc.date.available2025-12-11T11:07:20Z
dc.date.issued2025
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground: Previous reports from relatively small clinical cohorts have suggested that the clinical presentation of obstructive sleep apnea (OSA) differs between men and women. Objective: We aimed to explore sex differences in clinical and polysomnographic features of OSA in a large nationwide registry. Methods: Participants from the ongoing Turkish Sleep Apnea Database (TURKAPNE) Study from 34 centers were included in the current analysis. OSA was defined as an apnea-hypopnea index (AHI) ≥5 events/hour and was classified as mild, moderate, and severe according to AHI cut-offs 5, 15, and 30 events/hour, respectively. Results: In all, 7130 patients (2259 women) were included. OSA was observed in 6323 (88.7 %), of whom 70.2 % were male and 29.8 % were female. In the OSA group, women were older (56.7 ± 11.9 vs. 49.5 ± 11.3 years; p < 0.001) and more obese (body mass index 34.3 ± 7.2 vs. 31.4 ± 5.6 kg/m2; p < 0.001) and had lower AHI (29.8 ± 24.1 vs. 36.8 ± 26.2 events/h; p < 0.001) than men. Loud snoring and witnessed apnea were more common in men than in women whereas women were more frequently presented with insomnia, headache, and mood changes. Women had significantly less total sleep time, less sleep efficiency, and longer sleep latency compared with men (p < 0.001 for each). Additionally, comorbid diseases such as diabetes mellitus, hypertension, asthma, psychiatric disorders, hypothyroidism as well as drug use were more common in women than in men independent of age and obesity (p < 0.05 for each). Conclusions: Our results suggest significant sex differences in clinical and polysomnographic features in this nationwide Turkish adult population. Women with OSA have more symptom burden and comorbidities despite having a less severe AHI.
dc.description.sponsorshipTurkish Thoracic Society
dc.identifier.citationPıhtılı, A., Kıyan, E., Balcan, B., Arbatlı, S., Çilli, A., Altıntaş, N. ... Akkoyunlu, M. E. (2025). Sex differences in clinical and polysomnographic features of obstructive sleep apnea: The Turkish sleep apnea database (TURKAPNE) cohort. Sleep Medicine, 126, 228-234. http://dx.doi.org/10.1016/j.sleep.2024.12.018
dc.identifier.doi10.1016/j.sleep.2024.12.018
dc.identifier.endpage234
dc.identifier.issn1389-9457
dc.identifier.issn1878-5506
dc.identifier.pmid39721358
dc.identifier.scopus2-s2.0-85212914713
dc.identifier.scopusqualityQ1
dc.identifier.startpage228
dc.identifier.urihttp://dx.doi.org/10.1016/j.sleep.2024.12.018
dc.identifier.urihttps://hdl.handle.net/20.500.12511/13328
dc.identifier.volume126
dc.identifier.wosWOS:001394481500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAkkoyunlu, Muhammed Emin
dc.language.isoen
dc.relation.ispartofSleep Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectObstructive Sleep Apnea
dc.subjectPolysomnography
dc.subjectSex
dc.subjectSymptoms
dc.titleSex differences in clinical and polysomnographic features of obstructive sleep apnea: The Turkish sleep apnea database (TURKAPNE) cohort
dc.typeArticle

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