Stroke induces disease-specific myeloid cells in the brain parenchyma and pia

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dc.authorid0000-0001-6494-8923
dc.contributor.authorBeuker, Carolin
dc.contributor.authorSchafflick, David
dc.contributor.authorStrecker, Jan-Kolja
dc.contributor.authorHeming, Michael
dc.contributor.authorLi, Xiaolin
dc.contributor.authorWolbert, Jolien
dc.contributor.authorSchmidt-Pogoda, Antje
dc.contributor.authorThomas, Christian
dc.contributor.authorKuhlmann, Tanja
dc.contributor.authorAranda-Pardos, Irene
dc.contributor.authorA-Gonzalez, Noelia
dc.contributor.authorKumar, Praveen Ashok
dc.contributor.authorWerner, Yves
dc.contributor.authorKılıç, Ertuğrul
dc.contributor.authorHermann, Dirk M.
dc.contributor.authorWiendl, Heinz
dc.contributor.authorStumm, Ralf
dc.contributor.authorzu Hörste, Gerd Meyer
dc.contributor.authorMinnerup, Jens
dc.date.accessioned2022-02-25T07:43:06Z
dc.date.available2022-02-25T07:43:06Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.description.abstractInflammation triggers secondary brain damage after stroke. The meninges and other CNS border compartments serve as invasion sites for leukocyte influx into the brain thus promoting tissue damage after stroke. However, the post-ischemic immune response of border compartments compared to brain parenchyma remains poorly characterized. Here, we deeply characterize tissue-resident leukocytes in meninges and brain parenchyma and discover that leukocytes respond differently to stroke depending on their site of residence. We thereby discover a unique phenotype of myeloid cells exclusive to the brain after stroke. These stroke-associated myeloid cells partially resemble neurodegenerative disease-associated microglia. They are mainly of resident microglial origin, partially conserved in humans and exhibit a lipid-phagocytosing phenotype. Blocking markers specific for these cells partially ameliorates stroke outcome thus providing a potential therapeutic target. The injury-response of myeloid cells in the CNS is thus compartmentalized, adjusted to the type of injury and may represent a therapeutic target.
dc.identifier.citationBeuker, C., Schafflick, D., Strecker, Jan-K., Heming, M., Li, X., Wolbert, J. ... Minnerup, J. (2022). Stroke induces disease-specific myeloid cells in the brain parenchyma and pia. Nature Communications, 13(1), 945-945. http://doi.org/10.1038/s41467-022-28593-1
dc.identifier.doi10.1038/s41467-022-28593-1
dc.identifier.endpage945
dc.identifier.issn2041-1723
dc.identifier.issue1
dc.identifier.pmid35177618
dc.identifier.scopus2-s2.0-85124776410
dc.identifier.scopusqualityQ1
dc.identifier.startpage945
dc.identifier.urihttp://doi.org/10.1038/s41467-022-28593-1
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9004
dc.identifier.volume13
dc.identifier.wos000757851300022en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKılıç, Ertuğrul
dc.language.isoen
dc.publisherNLM (Medline)
dc.relation.ispartofNature Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectBrain Parenchyma
dc.subjectPia
dc.subjectMyeloid Cells
dc.subjectStroke Disease
dc.titleStroke induces disease-specific myeloid cells in the brain parenchyma and pia
dc.typeArticle

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