What is the incidence of celiac disease in patients with microscopic colitis? Why are these two diseases related?

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dc.authorid0000-0002-2197-0466
dc.contributor.authorEbik, Berat
dc.contributor.authorEkin, Nazım
dc.contributor.authorBacaksız, Ferhat
dc.contributor.authorÜzel, Ali
dc.contributor.authorAkkuzu, Mustafa Zanyar
dc.contributor.authorUçmak, Feyzullah
dc.contributor.authorKaya, Muhsin
dc.contributor.authorGöral, Vedat
dc.date.accessioned2024-05-08T11:52:14Z
dc.date.available2024-05-08T11:52:14Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractIntroduction: Although there are studies in the literature showing that celiac disease (CD) is more common in patients with microscopic colitis (MC), there are publications to the contrary. The pathophysiologies of both diseases are different from each other. Aim: To investigate the frequency of CD in MC patients, the different features of these 2 diseases, and the relationship between them. Material and methods: In our prospective and cross-sectional analytical study, the presence of CD was investigated in 90 patients diagnosed with MC by colonoscopy and biopsy due to chronic diarrhoea between September 2011 and December 2021. Results: We detected MC in 102 (9.3%) of 1096 patients investigated for chronic diarrhoea. We detected CD in 1 (1.1%) of 90 patients with MC who participated in the study. Only 10% of the patients were positive for AGA IgA, 3.3% for EMA IgA, and 2.2% for Anti-TG2 IgA. There was no difference in autoantibody titre in treatment-responsive and treatment-resistant MC patients. HLA DQ2 was positive in 32.2% (n = 29) of the MC patients, and HLA DQ8 was found in 5.5% (n = 5). Intraepithelial lymphocyte increase was remarkable in the duodenal biopsies of MC patients who did not respond to treatment (40% vs. 11.4%; p = 0.007). Conclusions: We did not reach the conclusion that CD is more common in MC patients. An increase in IEL may also occur in the small intestine in patients with MC who do not respond to treatment.
dc.identifier.citationEbik, B., Ekin, N., Bacaksız, F., Üzel, A., Akkuzu, M. Z., Uçmak, F. ... Göral, V. (2024). What is the incidence of celiac disease in patients with microscopic colitis? Why are these two diseases related?. Przeglad Gastroenterologiczny, 19(1), 81-88. http://dx.doi.org/10.5114/pg.2023.126855
dc.identifier.doi10.5114/pg.2023.126855
dc.identifier.endpage88
dc.identifier.issn1895-5770
dc.identifier.issn1897-4317
dc.identifier.issue1
dc.identifier.pmid38571542
dc.identifier.scopus2-s2.0-85189374435
dc.identifier.scopusqualityQ3
dc.identifier.startpage81
dc.identifier.urihttp://dx.doi.org/10.5114/pg.2023.126855
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12438
dc.identifier.volume19
dc.identifier.wos001197272000010en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGöral, Vedat
dc.language.isoen
dc.relation.ispartofPrzeglad Gastroenterologicznyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectCeliac Disease
dc.subjectIncidence
dc.subjectMicroscopic Colitis
dc.titleWhat is the incidence of celiac disease in patients with microscopic colitis? Why are these two diseases related?
dc.typeArticle

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