The therapeutic role of repetitive transcranial magnetic stimulation (rTMS) in parkinsonian visual hallucinations: Electrophysiological correlates

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dc.authorid0000-0003-4292-5717
dc.authorid0000-0002-0860-0524
dc.authorid0000-0002-7555-3801
dc.contributor.authorHanoğlu, Taha
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorGüntekin, Bahar
dc.contributor.authorAktürk, Tuba
dc.contributor.authorYuluğ, Burak
dc.date.accessioned2019-12-19T13:10:04Z
dc.date.available2019-12-19T13:10:04Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Elektronörofizyoloji Ana Bilim Dalı
dc.description.abstractWe have evaluated an 82 years old PD patient who has acutely developed VH secondary to acute visual loss that was associated with increased electroencephalographic activity in the gamma range over the parietal, occipital and frontal regions. In this respect, we have tested the therapeutic effect of occipital lobe oriented rTMS application and its electrophysiological correlates that led to significant improvement in the hallucinatory symptomatology of the patient after two weeks. We have revealed that the improved hallucinatory symptoms after rTMS application resolved completely after switching from the pramipexole treatment to L-Dopa indicating that there could be a combined therapeutic effect of L-Dopa and rTMS. Furthermore, Quantitative-Electroencephalography analysis has shown that the therapeutic effects of rTMS and L-Dopa were seen with the improvement of impaired gamma power spectrum. Although the main limitation of this report is that this a single case study and that these findings need to be replicated in a larger sample, e.g., as part of a controlled trial, our present findings help us to enlighten the unknown pathophysiological overlapping between the visual hallucinations in PD and Charles Bonnet Syndrome. Finally, our study revealed increased gamma coherence and power spectrum which is seen with visual hallucinations and improved after the application of 1 Hz rTMS on the occipital lobe. These findings together suggest that rTMS could be used as a therapeutic tool for parkinsonian complex VH and probably due affecting gamma coherence and power spectrum.
dc.identifier.citationHanoğlu, T., Hanoğlu, L., Güntekin, B., Aktürk, T. ve Yuluğ, B. (2019). The therapeutic role of repetitive transcranial magnetic stimulation (rTMS) in parkinsonian visual hallucinations: Electrophysiological correlates. Journal of Clinical Neuroscience, 69, 281-284. https://doi.org/10.1016/j.jocn.2019.08.002
dc.identifier.doi10.1016/j.jocn.2019.08.002
dc.identifier.endpage284
dc.identifier.issn0967-5868
dc.identifier.issn1532-2653
dc.identifier.scopusqualityQ2
dc.identifier.startpage281
dc.identifier.urihttps://doi.org/10.1016/j.jocn.2019.08.002
dc.identifier.urihttps://hdl.handle.net/20.500.12511/4558
dc.identifier.volume69
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Ltd
dc.relation.ispartofJournal of Clinical Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectrTMS
dc.subjectVisual Hallucination
dc.subjectParkinson’s Disease
dc.subjectCharles Bonnet Syndrome
dc.subjectQ-EEG
dc.subjectCoherence
dc.subjectPower Spectrum
dc.subjectGamma Activity
dc.titleThe therapeutic role of repetitive transcranial magnetic stimulation (rTMS) in parkinsonian visual hallucinations: Electrophysiological correlates
dc.typeArticle

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