Serum, saliva, and gingival tissue human beta-defensin levels in relation to retinoic acid use

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dc.authorid0000-0002-7243-5391
dc.authorid0000-0001-7986-7085
dc.authorid0000-0003-2901-4249
dc.contributor.authorAtalay, Nur
dc.contributor.authorBalcı, Nur
dc.contributor.authorUslu Toygar, Hilal
dc.contributor.authorYardımcı, Gürkan
dc.contributor.authorGürsoy, Ulvi Kahraman
dc.date.accessioned2023-06-09T06:50:16Z
dc.date.available2023-06-09T06:50:16Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Periodontoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, Periodontoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Deri ve Zührevi Hastalıklar Ana Bilim Dalı
dc.description.abstractBackgroundRetinoic acid is an active derivative of vitamin A and regulates the differentiation, proliferation, and antimicrobial peptide expression profiles of human cells. The aim of the present study was to analyze the effect of systemic retinoic acid use on serum, saliva, and gingival tissue levels of human beta-defensin (hBD)-1, hBD-2, and hBD-3. MethodsA total of 69 participants (34 systemic retinoic acid users and 35 healthy controls) were enrolled in this study. Plaque index, probing pocket depth, bleeding on probing (BOP), and clinical attachment loss were measured. Saliva and serum hBD-1, hBD-2, and hBD-3 levels were quantified by enzyme-linked immunosorbent assay. Gingival tissue hBD-1, hBD-2, and hBD-3 levels were determined by immunohistochemistry. A univariate general linear model was used in adjusted comparisons of hBD1, hBD-2, and hBD-3. P values of < 0.05 were considered statistically significant. ResultsReduced salivary levels of hBD-2 (P = 0.042), but not hBD-1 or hBD-3, were detected in systemic retinoic acid users compared to non-user controls. There was a significant difference in the adjusted (for BOP%) salivary hBD-2 concentrations between retinoic acid and control groups (P = 0.031). No difference was observed in serum or tissue levels of hBD-1, hBD-2, or hBD-3 between the two study groups. ConclusionSystemic retinoic acid use was associated with suppressed salivary hBD-2 level, which was independent of gingival inflammation.
dc.identifier.citationAtalay, N., Balcı, N., Uslu Toygar, H., Yardımcı, G. ve Gürsoy, U. K. (2023). Serum, saliva, and gingival tissue human beta-defensin levels in relation to retinoic acid use. Journal of Periodontology, 94(5), 597-605. https://doi.org/10.1002/JPER.22-0466
dc.identifier.doi10.1002/JPER.22-0466
dc.identifier.endpage605
dc.identifier.issn0022-3492
dc.identifier.issn1943-3670
dc.identifier.issue5
dc.identifier.pmid36440958
dc.identifier.scopus2-s2.0-85144264764
dc.identifier.scopusqualityQ1
dc.identifier.startpage597
dc.identifier.urihttps://doi.org/10.1002/JPER.22-0466
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11052
dc.identifier.volume94
dc.identifier.wos000992038600001en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAtalay, Nur
dc.institutionauthorBalcı, Nur
dc.institutionauthorUslu Toygar, Hilal
dc.institutionauthorYardımcı, Gürkan
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Periodontologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectDefensins
dc.subjectGingiva
dc.subjectPeriodontium
dc.subjectRetinoids
dc.subjectSaliva
dc.subjectSerum
dc.titleSerum, saliva, and gingival tissue human beta-defensin levels in relation to retinoic acid use
dc.typeArticle

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