Blood pressure parameters affecting ventricular repolarization in obese children

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dc.authorid0000-0002-3582-5075
dc.contributor.authorKasap Demir, Belde
dc.contributor.authorSoyaltın, Eren
dc.contributor.authorAlparslan, Caner
dc.contributor.authorDemircan, Tülay
dc.contributor.authorArslansoyu Çamlar, Seçil
dc.contributor.authorAlaygut, Demet
dc.contributor.authorMutlubaş, Fatma
dc.contributor.authorÖncel, Elif Perihan
dc.contributor.authorYavaşcan, Önder
dc.contributor.authorDündar, Bumin Nuri
dc.contributor.authorKaradeniz, Cem
dc.date.accessioned2024-01-10T12:47:17Z
dc.date.available2024-01-10T12:47:17Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground Ventricular repolarization (VR) increases the risk of sudden cardiac death due to ventricular arrhythmia. We aimed to evaluate the blood pressure (BP) parameters affecting VR in obese children.Methods Obese (BMI = 95p) and healthy children = 120 cm between January 2017 and June 2019 were included. Demographic and laboratory data, peripheral and central BPs evaluated by a device capable of ambulatory blood pressure monitoring (ABPM), and pulse wave analysis were assessed. Electrocardiographic ventricular repolarization indices, left ventricular mass index (LVMI), and relative wall thickness (RWT) were calculated.Results A total of 52 obese and 41 control patients were included. Uric acid, triglyceride, total cholesterol, LDL, and ALT values, systolic and diastolic office BPs, 24-h, daytime and nighttime systolic and mean arterial BPs, daytime diastolic BP SDS levels, daytime and nighttime systolic loads, daytime diastolic load, 24-h, daytime and nighttime central systolic and diastolic BPs, and pulse wave velocity values were significantly higher, whereas 24-h, daytime and nighttime AIx@75 were similar between the groups. fT4 levels of obese cases were significantly lower. QTcd and Tp-ed were higher in obese patients. Although RWT was higher in obese cases, LVMI values and cardiac geometry classifications were similar. The independent factors affecting VR in obese cases were younger age and higher diastolic load at night (B = - 2.83, p = 0.010; B = 0.257, p = 0.007, respectively).Conclusion Obese patients have higher peripheral and central BP, arterial stiffness, and higher VR indices that develop before an increase in LVMI. It would be useful to prevent obesity from an early age and follow up nighttime diastolic load to control VR associated sudden cardiac death in obese children.
dc.description.sponsorshipIzmir Katip Celebi University Scientific Research Projects Coordination Uniten_US
dc.identifier.citationKasap Demir, B., Soyaltın, E., Alparslan, C., Demircan, T., Arslansoyu Çamlar, S., Alaygut, D. ... Karadeniz, C. (2023). Blood pressure parameters affecting ventricular repolarization in obese children. Pediatric Nephrology, 38(10), 3359-3367. https://dx.doi.org/10.1007/s00467-023-05971-5
dc.identifier.doi10.1007/s00467-023-05971-5
dc.identifier.endpage3367
dc.identifier.issn0931-041X
dc.identifier.issn1432-198X
dc.identifier.issue10
dc.identifier.pmid37140711
dc.identifier.scopus2-s2.0-85157977223
dc.identifier.scopusqualityQ1
dc.identifier.startpage3359
dc.identifier.urihttps://dx.doi.org/10.1007/s00467-023-05971-5
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12119
dc.identifier.volume38
dc.identifier.wos000982065000003en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYavaşcan, Önder
dc.language.isoen
dc.publisherSpringer Science and Business Media Deutschland GmbH
dc.relation.ispartofPediatric Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectObesity
dc.subjectChildren
dc.subjectVentricular Repolarization Dispersion
dc.subjectArterial Stifness
dc.subjectPulse Wave Velocity
dc.subjectAugmentation Index
dc.subjectBlood Pressure
dc.titleBlood pressure parameters affecting ventricular repolarization in obese children
dc.typeArticle

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