Isoflavones obtained from red clover improve both dyslipidemia and menopausal symptoms in menopausal women: a prospective randomized placebo-controlled trial

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dc.contributor.authorYiğit, Ece
dc.contributor.authorÜnsal, Saadet
dc.date.accessioned2025-06-10T12:19:38Z
dc.date.available2025-06-10T12:19:38Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractObjective: This study aimed to investigate the effects of red clover isoflavones on menopausal symptoms and the lipid profile in menopausal females. Methods: This study included postmenopausal women with dyslipidemia. The red clover group (n = 39) received 40 mg isoflavone red clover capsule twice daily for 6 months, while placebo (n = 36) was 40 mg starch capsule twice daily. Data were collected at baseline, 3 months and 6 months. The Menopause Rating Scale (MRS) was applied to calculate subdimension and total scores. Results: The two groups were similar in terms of age, MRS and lipid profile at baseline. In the red clover group, MRS scores decreased significantly at both 3 and 6 months. Similarly, total cholesterol, low-density lipoprotein cholesterol (LDL-C) and triglyceride levels decreased at both 3 months and 6 months. High-density lipoprotein cholesterol increased significantly from baseline to 3 months and 6 months. Except for LDL-C and MRS urogenital score at 3 months, the improvements were significantly in favor of red clover isoflavone treatment. Conclusions: Red clover treatment for 3–6 months demonstrated significant improvements in lipid profiles and menopausal symptoms. While promising, further research is crucial to ascertain long-term safety and recommend the use of red clover isoflavones during menopause.
dc.identifier.citationYiğit, E. ve Ünsal, S. (2024). Isoflavones obtained from red clover improve both dyslipidemia and menopausal symptoms in menopausal women: a prospective randomized placebo-controlled trial. Climacteric, 27(6), 548-554. http://dx.doi.org/10.1080/13697137.2024.2393121
dc.identifier.doi10.1080/13697137.2024.2393121
dc.identifier.endpage554
dc.identifier.issn1369-7137
dc.identifier.issue6
dc.identifier.pmid39254422
dc.identifier.scopus2-s2.0-85203426191
dc.identifier.scopusqualityQ1
dc.identifier.startpage548
dc.identifier.urihttp://dx.doi.org/10.1080/13697137.2024.2393121
dc.identifier.uri1473-0804
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12938
dc.identifier.volume27
dc.identifier.wosWOS:001309057900001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYiğit, Ece
dc.institutionauthorÜnsal, Saadet
dc.institutionauthorid0000-0002-8293-3554
dc.institutionauthorid0000-0001-7953-9866
dc.language.isoen
dc.relation.ispartofClimacteric
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDyslipidemia
dc.subjectMenopause
dc.subjectMenopause Rating Scale
dc.subjectPlacebo
dc.subjectRed Clover
dc.titleIsoflavones obtained from red clover improve both dyslipidemia and menopausal symptoms in menopausal women: a prospective randomized placebo-controlled trial
dc.typeArticle

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