The difference between planned and delivered dose for head and neck cancer, and the consequences for normal tissue toxicity probability

Basit Öğe Kaydı
dc.contributor.authorHeukelom, Jolien
dc.contributor.authorKantor, Michael E.
dc.contributor.authorMohamed, Abdallah S. R.
dc.contributor.authorElhalawani, Hesham
dc.contributor.authorKoçak, Esengül
dc.contributor.authorLin, Timothy A.
dc.contributor.authorWilliamson, Ryan
dc.contributor.authorRasch, Coen
dc.contributor.authorFuller, Clifton David
dc.contributor.authorSonke, Jan Jakob
dc.date.accessioned2021-01-18T08:33:55Z
dc.date.available2021-01-18T08:33:55Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyasyon Onkolojisi Ana Bilim Dalı
dc.description.abstractPurpose/Objective(s): Anatomical changes during radiation for head andneck cancer (HNC) induce differences between the planned and delivereddose. To account for this, an adapted treatment plan can be designed. Thedecision to do this is based on expert opinion after examination of inroomimages. The aims of this study were to 1. quantify the difference betweenplanned and delivered dose in HNC patients. 2. assess the consequentialdifference in normal tissue complication probability (DNTCP). 3. Assessthe positive predictive value (PPV) for the allocation of adaptive radiotherapy (ART) of clinical judgement vs. NTCP based on dose differencesat fraction 10 (F10) and 15 (F15).Materials/Methods: Daily CT scans in treatment position for 56 patientswere retrospectively analyzed. Delivered dose was calculated based on theanatomy of the day and subsequently mapped back to the planning CT toallow dose accumulation. The difference between planned and delivereddose was analyzed for CTVs and 9 organs at risk (OAR). DNTCP wascalculated for xerostomia, dysphagia, parotid gland dysfunction and tubefeeding dependency at 6 months post treatment (Tube6m) using previouslypublished NTCP models. ART was deemed necessary if DNTCP was>5%. To predict DNTCP at the end of treatment using the dose differenceat F10 or F15, the dose on that day was extrapolated to the full treatmentlength prior to the NTCP calculation. The PPV was calculated for identification of ART-patients by clinical judgement, DNTCP at F10 and F15.
dc.description.sponsorshipElekta AB ; American Society for Radiation Oncology (ASTRO)en_US
dc.identifier.citationHeukelom, J., Kantor, M. E., Mohamed, A. S. R., Elhalawani, H., Koçak, E., Lin, T. A. ... Sonke, J. J. (2018). The difference between planned and delivered dose for head and neck cancer, and the consequences for normal tissue toxicity probability. 60th Annual Meeting of the American-Society-for-Radiation-Oncology (ASTRO) içinde (E224-E225. ss.). San Antonio, TX, October 21-24, 2018. https://dx.doi.org/10.1016/j.ijrobp.2018.07.770
dc.identifier.doi10.1016/j.ijrobp.2018.07.770
dc.identifier.endpageE225
dc.identifier.issn0360-3016
dc.identifier.issn1879-355X
dc.identifier.issue3
dc.identifier.startpageE224
dc.identifier.urihttps://dx.doi.org/10.1016/j.ijrobp.2018.07.770
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6272
dc.identifier.volume102
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartof60th Annual Meeting of the American-Society-for-Radiation-Oncology (ASTRO)en_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectNeck Cancer
dc.subjectConsequences
dc.subjectNormal Tissue
dc.subjectToxicity Probability
dc.titleThe difference between planned and delivered dose for head and neck cancer, and the consequences for normal tissue toxicity probability
dc.typeConference Object

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
Kocak-Esengül-2018.pdf
Boyut:
331.59 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Bildiri Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu