Poor reactivity of posterior electroencephalographic alpha rhythms during the eyes open condition in patients with dementia due to Parkinson's disease

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dc.authorid0000-0002-0860-0524
dc.authorid0000-0002-7715-3035
dc.authorid0000-0003-4292-5717
dc.contributor.authorBabiloni, Claudio
dc.contributor.authorNoce, Giuseppe
dc.contributor.authorTucci, Federico
dc.contributor.authorJakhar, Dharmendra
dc.contributor.authorFerri, Raffaele
dc.contributor.authorPanerai, Simonetta
dc.contributor.authorCatania, Valentina
dc.contributor.authorSoricelli, Andrea
dc.contributor.authordel Percio, Claudio
dc.date.accessioned2024-01-05T10:25:39Z
dc.date.available2024-01-05T10:25:39Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Elektronörofizyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalı
dc.description.abstractHere, we hypothesized that the reactivity of posterior resting-state electroencephalographic (rsEEG) alpha rhythms during the transition from eyes-closed to -open condition might be lower in patients with Parkinson's disease dementia (PDD) than in patients with Alzheimer's disease dementia (ADD). A Eurasian database provided clinical-demographic-rsEEG datasets in 73 PDD patients, 35 ADD patients, and 25 matched cognitively unimpaired (Healthy) persons. The eLORETA freeware was used to estimate cortical rsEEG sources. Results showed substantial (greater than ?10%) reduction (reactivity) in the posterior alpha source activities from the eyes-closed to the eyes-open condition in 88% of the Healthy seniors, 57% of the ADD patients, and only 35% of the PDD patients. In these alpha-reactive participants, there was lower reactivity in the parietal alpha source activities in the PDD group than in the healthy control seniors and the ADD patients. These results suggest that PDD patients show poor reactivity of mechanisms desynchronizing posterior rsEEG alpha rhythms in response to visual inputs. That neurophysiological biomarker may provide an endpoint for (non) pharmacological interventions for improving vigilance regulation in those patients.
dc.description.sponsorshipEuropean Consortium of Dementia ; IRCCS San Raffaele Rome ; World Medical Association ; Ministero della Salute ; Sapienza Università di Romaen_US
dc.identifier.citationBabiloni, C., Noce, G., Tucci, F., Jakhar, D., Ferri, R., Panerai, S. ... del Percio, C. (2024). Poor reactivity of posterior electroencephalographic alpha rhythms during the eyes open condition in patients with dementia due to Parkinson's disease. Neurobiology of Aging, 135, 1-14. https://dx.doi.org/10.1016/j.neurobiolaging.2023.11.010
dc.identifier.doi10.1016/j.neurobiolaging.2023.11.010
dc.identifier.endpage14
dc.identifier.issn0197-4580
dc.identifier.pmid38142464
dc.identifier.scopus2-s2.0-85180581915
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttps://dx.doi.org/10.1016/j.neurobiolaging.2023.11.010
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12093
dc.identifier.volume135
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGüntekin, Bahar
dc.institutionauthorYıldırım, Ebru
dc.institutionauthorHanoğlu, Lütfü
dc.language.isoen
dc.publisherElsevier Inc.
dc.relation.ispartofNeurobiology of Agingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAlzheimer's Disease Dementia (ADD)
dc.subjectDesynchronization of Alpha Rhythms
dc.subjectExact Low-Resolution Brain Electromagnetic Source Tomography (eLORETA)
dc.subjectEyes Closed
dc.subjectParkinson's Disease Dementia (PDD)
dc.subjectResting-State Electroencephalographic (EEG) Rhythms
dc.subjectResting-State Eyes Open
dc.titlePoor reactivity of posterior electroencephalographic alpha rhythms during the eyes open condition in patients with dementia due to Parkinson's disease
dc.typeArticle

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