Predictors of symptom development in intermediate carotid artery stenosis: Mean platelet volume and platelet distribution width

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dc.authorid0000-0003-1919-3183
dc.contributor.authorKöklü, Erkan
dc.contributor.authorYüksel, İsa Öner
dc.contributor.authorArslan, Şakir
dc.contributor.authorÇağırcı, Göksel
dc.contributor.authorSarıönder Gencer, Elif
dc.contributor.authorKoç, Pınar
dc.contributor.authorÇay, Serkan
dc.contributor.authorKızılırmak, Filiz
dc.contributor.authorEsin, Murat
dc.date.accessioned2020-07-08T14:08:01Z
dc.date.available2020-07-08T14:08:01Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.description.abstractPlatelets play an important role in the pathogenesis of atherothrombosis. Platelet activation is associated with increased mean platelet volume (MPV) and platelet distribution width (PDW). In this study, we investigated the relation of MPV and PDW with the risk of stroke in patients with intermediate (50%-70%) carotid artery stenosis. A total of 254 patients (115 symptomatic and 139 asymptomatic) with intermediate carotid artery stenosis were enrolled in this study. Symptomatic and asymptomatic patients were compared in regard to MPV and PDW. Mean platelet volume was significantly greater in the symptomatic group compared with the asymptomatic group (11.1 and 9.4 fL, respectively; P < .001). Platelet distribution width was significantly greater in the symptomatic group compared with the asymptomatic group (15.0% and 11.9%, respectively; P < .001). Multivariate regression analysis showed that an MPV 10.2 fL and a PDW 14.3% were independent predictors of developing symptomatic carotid artery stenosis. Mean platelet volume and PDW are increased in the presence of symptomatic intermediate carotid artery stenosis. Increased MPV and PDW may be independent predictors of developing symptomatic carotid artery plaque.
dc.identifier.citationKöklü, E., Yüksel, İ. Ö., Arslan, Ş., Çağırcı, G., Sarıönder Gencer, E., Koç, P. ... Esin, M. (2016). Predictors of symptom development in intermediate carotid artery stenosis: Mean platelet volume and platelet distribution width. Angiology, 67(7), 622-629. https://dx.doi.org/10.1177/0003319715613916
dc.identifier.doi10.1177/0003319715613916
dc.identifier.endpage629
dc.identifier.issn0003-3197
dc.identifier.issn1940-1574
dc.identifier.issue7
dc.identifier.startpage622
dc.identifier.urihttps://dx.doi.org/10.1177/0003319715613916
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5427
dc.identifier.volume67
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSAGE Publications
dc.relation.ispartofAngiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectCarotid Artery Stenosis
dc.subjectMean Platelet Volume
dc.subjectPlatelet Distribution Width
dc.subjectStroke
dc.titlePredictors of symptom development in intermediate carotid artery stenosis: Mean platelet volume and platelet distribution width
dc.typeArticle

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