Vitamin d and elevated serum uric acid as novel predictors and prognostic markers for type 2 diabetes mellitus

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dc.contributor.authorBener, Abdulbari
dc.contributor.authorAl-Hamaq, Abdulla Omar A.A.
dc.contributor.authorÖztürk, Mustafa
dc.contributor.authorTewfik, Ihab
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:49:37Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:49:37Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000466839700003
dc.descriptionPubMed ID: 31148888
dc.description.abstractAim: To ascertain the active role of uric acid and vitamin D as potential biomarkers for impaired glucose metabolism among people living with type 2 diabetes mellitus (T2DM) in Turkish community. Subjects and Methods: This study was based on 680 patients with T2DM and 680 healthy subjects aged between 25 and 70 years, who visited the diabetes and endocrinology department of Istanbul Mega Medipol University Teaching Hospital, Istanbul, Turkey, during January 2016 to April 2018. The investigated biochemical indices included lipid profiles (low-density lipoprotein [LDL], high-density lipoprotein, total cholesterol, and triglyceride [TG]), uric acid, blood pressure (BP), serum creatinine, glycosylated hemoglobin (HbA1c), thyroid-stimulating hormone (TSH), postprandial glucose, and any related comorbidities. Results: This study reported significant differences between family history duration of patients with T2DM of <= 5 and >5 years when compared to that of control subjects with respect to body mass index (BMI), smoking habit, sheesha smoking, income, family history of metabolic syndrome, hypertension, coronary heart disease, and nephropathy. Similarly, significant differences were found between patients with T2DM (with family history T2DM duration of less than 5 years and more than 5 years in contrast to healthy subjects' level of LDL, TG, fasting blood glucose, HbA1c, systolic BP (SBP), bilirubin, albumin, magnesium, potassium, calcium, number of sleeping hours, and TSH. We uncovered the correlation between serum uric acid level with the clinical biochemical indices related to T2DM: serum calcium (r = 0.336), magnesium (r = 0.272), potassium (r = 0.205), HbA1c (r = 0.638), fasting blood glucose (P = 0.486), bilirubin (r = 0.251), albumin (r = 0.285), LDL (r = 0.322), TG (r = 0.434), diastolic BP (DBP) (r = 0.392), SBP (r = 0.344), BMI (r = 0.482), waist circumference (WC) (r = 0.366), age (r = 0.217), number of sleeping hours (r = 0.275), and TSH (r = 0.445). Multivariate stepwise logistic regression showed that variables, such as serum vitamin D, uric acid, TSH, HbA1c, DBP, WC, BMI, and SBP, were considered at higher risk as significant (P <0.001) predictors for T2DM. Conclusion: The results suggest strong positive correlation between serum uric acid level with BP (SBP and DBP), age, BMI, and WC among patients with T2DM. This study ascertains that an increase in uric acid level may be due to elevated level of HbA1c, metabolic syndrome, diabetes, obesity, and/or hypertension.
dc.description.sponsorshipQatar Diabetes Association, Qatar Foundation, Doha, Qatar; Istanbul Medipol University [10840098-604.01.01-E.8421, 10840098-604.01.01-E.3193]en_US
dc.description.sponsorshipThis work was generously supported and funded by the Qatar Diabetes Association, Qatar Foundation, Doha, Qatar. We would like to thank the Istanbul Medipol University for their support and ethical approval (Research Protocol and IRB no. 10840098-604.01.01-E.8421 and Research Protocol and IRB no. 10840098-604.01.01-E.3193).en_US
dc.identifier.citationBener, A., Al-Hamaq, A. O. A.A., Öztürk, M. ve Tewfik, I. (2019). Vitamin d and elevated serum uric acid as novel predictors and prognostic markers for type 2 diabetes mellitus. Journal of Pharmacy and Bioallied Sciences, 11(2), 127-132. https://dx.doi.org/10.4103/jpbs.JPBS_240_18
dc.identifier.doi10.4103/jpbs.JPBS_240_18
dc.identifier.endpage132
dc.identifier.issn0975-7406
dc.identifier.issue2
dc.identifier.scopusqualityQ2
dc.identifier.startpage127
dc.identifier.urihttps://dx.doi.org/10.4103/jpbs.JPBS_240_18
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1679
dc.identifier.volume11
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofJournal of Pharmacy and Bioallied Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectBiomarker
dc.subjectEpidemiology
dc.subjectNephropathy
dc.subjectType 2 Diabetes Mellitus
dc.subjectUric Acid
dc.subjectVitamin D
dc.titleVitamin d and elevated serum uric acid as novel predictors and prognostic markers for type 2 diabetes mellitus
dc.typeArticle

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