The association between the preoperative prognostic nutritional index and the controlling nutritional status score on tumor stage, chemotherapeutic response and overall survival in ovarian cancer

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dc.contributor.authorKarakaş, Sema
dc.contributor.authorDemirayak, Gökhan
dc.contributor.authorÖnder, Ayşe Büşra
dc.contributor.authorÖzdemir, İsa Aykut
dc.contributor.authorComba, Cihan
dc.contributor.authorSüzen Çaypınar, Sema
dc.contributor.authorYıldız, Şükrü
dc.contributor.authorAvşar, Selim
dc.contributor.authorBağhaki, Sema
dc.contributor.authorYıldız, Güneş Özlem
dc.contributor.authorErdoğan, Şakir Volkan
dc.date.accessioned2023-01-12T11:36:28Z
dc.date.available2023-01-12T11:36:28Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.description.abstractObjective: This study aimed to investigate the association between preoperative prognostic nutritional index (PNI) and controlling nutritional status (CONUT) scores on the stage of ovarian cancer (OC), chemotherapeutic response, and overall survival (OS) in patients with OC. Methods: The data of the patients who operated due to OC between January 2015 and January 2020 in a tertiary referral hospital were recorded. The patients' basic characteristics, preoperative total cholesterol, albumin, lymphocyte count, tumor markers, disease stage, grade, chemotherapeutic response, OS, and progression-free survival were recorded. The PNI and the CONUT score were calculated. Results: The mean PNI level was considerably higher in the early-stage group than the advanced-stage group (50.02 +/- 6.8 vs. 46.3 +/- 7.4, p = 0.005). The AUC was 63% for the cutoff point 45.98 of PNI, whereas the AUC was 42% for the cutoff point 1.5 of CONUT score in predicting early-stage disease. The PFS and OS were significantly higher in the high PNI group than the low PNI group (p = 0.01, p = 0.002, respectively). Conclusion: The patients with early-stage OC had significantly higher PNI levels and lower CONUT scores in our study population.
dc.identifier.citationKarakaş, S., Demirayak, G., Önder, A. B., Özdemir, İ. A., Comba, C., Süzen Çaypınar, S. ... Erdoğan, Ş. V. (2022). The association between the preoperative prognostic nutritional index and the controlling nutritional status score on tumor stage, chemotherapeutic response and overall survival in ovarian cancer. Nutrition and Cancer, 74(5), 1770-1779. https://dx.doi.org/10.1080/01635581.2021.2022170
dc.identifier.doi10.1080/01635581.2021.2022170
dc.identifier.endpage1779
dc.identifier.issn0163-5581
dc.identifier.issn1532-7914
dc.identifier.issue5
dc.identifier.pmid34989281
dc.identifier.scopus2-s2.0-85122495058
dc.identifier.scopusqualityQ2
dc.identifier.startpage1770
dc.identifier.urihttps://dx.doi.org/10.1080/01635581.2021.2022170
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10296
dc.identifier.volume74
dc.identifier.wos000739682200001en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzdemir, İsa Aykut
dc.language.isoen
dc.publisherRoutledge Journals
dc.relation.ispartofNutrition and Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectOvarian Cancer
dc.subjectOverall Survival
dc.subjectPreoperative Prognostic Nutritional Index
dc.subjectControlling Nutritional Status Score
dc.titleThe association between the preoperative prognostic nutritional index and the controlling nutritional status score on tumor stage, chemotherapeutic response and overall survival in ovarian cancer
dc.typeArticle

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