Hexokinase 1 forms rings that regulate mitochondrial fission during energy stress

Basit Öğe Kaydı
dc.authorid0000-0003-0352-1947
dc.contributor.authorPilic, Johannes
dc.contributor.authorGottschalk, Benjamin
dc.contributor.authorBourgeois, Benjamin
dc.contributor.authorHabisch, Hansjörg
dc.contributor.authorKoshenov, Zhanat
dc.contributor.authorOflaz, Furkan Enes
dc.contributor.authorErdoğan, Yusuf Can
dc.contributor.authorMiri, Seyed Mohammad
dc.contributor.authorYiğit, Esra Nur
dc.contributor.authorAydın, Mehmet Şerif
dc.contributor.authorÖztürk, Gürkan
dc.contributor.authorEroğlu, Emrah
dc.contributor.authorShoshan Barmatz, Varda
dc.contributor.authorMadl, Tobias
dc.contributor.authorGraier, Wolfgang F.
dc.contributor.authorMalli, Roland
dc.date.accessioned2024-07-17T05:26:37Z
dc.date.available2024-07-17T05:26:37Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.description.abstractMetabolic enzymes can adapt during energy stress, but the consequences of these adaptations remain understudied. Here, we discovered that hexokinase 1 (HK1), a key glycolytic enzyme, forms rings around mitochondria during energy stress. These HK1-rings constrict mitochondria at contact sites with the endoplasmic reticulum (ER) and mitochondrial dynamics protein (MiD51). HK1-rings prevent mitochondrial fission by displacing the dynamin-related protein 1 (Drp1) from mitochondrial fission factor (Mff) and mitochondrial fission 1 protein (Fis1). The disassembly of HK1-rings during energy restoration correlated with mitochondrial fission. Mechanistically, we identified that the lack of ATP and glucose-6-phosphate (G6P) promotes the formation of HK1-rings. Mutations that affect the formation of HK1-rings showed that HK1-rings rewire cellular metabolism toward increased TCA cycle activity. Our findings highlight that HK1 is an energy stress sensor that regulates the shape, connectivity, and metabolic activity of mitochondria. Thus, the formation of HK1-rings may affect mitochondrial function in energy-stress-related pathologies.
dc.identifier.citationPilic, J., Gottschalk, B., Bourgeois, B., Habisch, H., Koshenov, Z., Oflaz, F. E. ... Malli, R. (2024). Hexokinase 1 forms rings that regulate mitochondrial fission during energy stress. Molecular Cell, 84(14), 2732-2746.e5. http://dx.doi.org/10.1016/j.molcel.2024.06.009
dc.identifier.doi10.1016/j.molcel.2024.06.009
dc.identifier.endpage274600000
dc.identifier.issn1097-2765
dc.identifier.issn1097-4164
dc.identifier.issue14
dc.identifier.pmid38981483
dc.identifier.scopus2-s2.0-85198581280
dc.identifier.scopusqualityQ1
dc.identifier.startpage2732
dc.identifier.urihttp://dx.doi.org/10.1016/j.molcel.2024.06.009
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12722
dc.identifier.volume84
dc.identifier.wos001282203200001en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorMiri, Seyed Mohammad
dc.institutionauthorYiğit, Esra Nur
dc.institutionauthorAydın, Mehmet Şerif
dc.institutionauthorÖztürk, Gürkan
dc.institutionauthorEroğlu, Emrah
dc.language.isoen
dc.relation.ispartofMolecular Cellen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectER-Mitochondria Contact Sites
dc.subjectEnergy Stress
dc.subjectGlucose Starvation
dc.subjectGlycolysis
dc.subjectHexokinase
dc.subjectLive-Cell Imaging
dc.subjectMitochondrial Constriction
dc.subjectMitochondrial Fission
dc.subjectNon-Catalytic Functions
dc.subjectProtein Cluster
dc.titleHexokinase 1 forms rings that regulate mitochondrial fission during energy stress
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Miri-Seyed Mohammad-2024.pdf
Boyut:
4.94 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Makale Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu