Attenuated cardiovascular response to sympathetic system activation during exercise in patients with dialysis-induced hypotension

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dc.contributor.authorFotbolcu, Hakan
dc.contributor.authorDuman, Dursun
dc.contributor.authorAlışır Ecder, Sebahat
dc.contributor.authorOduncu, Vecih
dc.contributor.authorÇevik, Cihan
dc.contributor.authorTigen, Kürşat
dc.contributor.authorŞirin, Gökçe
dc.contributor.authorÖzker, Emre
dc.contributor.authorKıran, Burak
dc.contributor.authorBaşaran, Yelda
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:35:30Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:35:30Z
dc.date.issued2011
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.description.abstractBackground: We wished to investigate potential causes of dialysis-induced hypotension (DIH), including the attenuated cardiovascular response to sympathetic system activation during exercise and myocardial dysfunction. Methods: This study included 26 end-stage renal disease (ESRD) patients with DIH, 30 ESRD patients without DIH (Non-DIH), and 30 control subjects. Each patient was evaluated with echocardiography and a symptom-limited treadmill stress test. The chronotropic index (CRI), heart rate recovery (HRR), systolic blood pressure response to exercise (SBP response), and tissue Doppler systolic myocardial velocities were calculated. Results: The HRR and velocities were reduced in dialysis patients compared to controls; however, they were similar in patients with and without DIH. Patients with DIH had the lowest CRI compared to theNon-DIH group (0.62 ± 0.15 vs. 0.73 ± 0.17, p = 0.020) and controls (0.62 ± 0.15 vs. 0.86 ± 0.11, p < 0.001). Similarly, patients with DIH had the lowest SBP response values compared to the Non-DIH (34.88 ± 15.01 vs. 55.67 ± 25.42, p = 0.002) and controls (34.88 ± 15.01 vs. 59.70 ± 23.04, p < 0.001). Conclusion: Patients with DIH have inadequate sympathetic activity of the cardiovascular system during exercise and impaired left ventricular systolic function. Both factors could contribute to the development of hypotension during hemodialysis.
dc.identifier.citationFotbolcu, H., Duman, D., Alışır Ecder, S., Oduncu, V., Çevik, C., Tigen, K. ... Başaran, Y. (2011). Attenuated cardiovascular response to sympathetic system activation during exercise in patients with dialysis-induced hypotension. American Journal of Nephrology, 33(6), 491-498. https://dx.doi.org/10.1159/000327829
dc.identifier.doi10.1159/000327829
dc.identifier.endpage498
dc.identifier.issn0250-8095
dc.identifier.issue6
dc.identifier.scopusqualityQ1
dc.identifier.startpage491
dc.identifier.urihttps://hdl.handle.net/20.500.12511/811
dc.identifier.urihttps://dx.doi.org/10.1159/000327829
dc.identifier.volume33
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKarger
dc.relation.ispartofAmerican Journal of Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAutonomic Nervous System
dc.subjectChronotropic Incompetence
dc.subjectDialysis
dc.subjectHeart Rate Recovery
dc.subjectHypotension
dc.subjectSystolic Blood Pressure
dc.titleAttenuated cardiovascular response to sympathetic system activation during exercise in patients with dialysis-induced hypotension
dc.typeArticle

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