The effects of surface functionality and size of gold nanoparticles on neuronal toxicity, apoptosis, ROS production and cellular/suborgan biodistribution

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dc.authorid0000-0002-8662-5284
dc.authorid0000-0001-8759-745X
dc.contributor.authorÖzçiçek, İlyas
dc.contributor.authorAyşit, Neşe
dc.contributor.authorÇakıcı, Çağrı
dc.contributor.authorAydeğer, Asel
dc.date.accessioned2021-08-05T06:45:31Z
dc.date.available2021-08-05T06:45:31Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.description.abstractGold nanoparticles are emerging as promising nanomaterials to create nanoscale therapeutic delivery systems. The aim of the study was to synthesis of highly monodisperse and stable gold nanoparticles functionalized with polyethyleneimine (PEI) and polyethylene glycol (PEG), multiparametric investigation of their neuronal toxi-cological effects and evaluation of the cellular/suborgan biodistribution. Gold nanoparticles (AuNP20 and AuNP50) were synthesized and their surfaces were electrostatically modified by PEI and PEG. Dorsal root gan-glion (DRG) sensory neurones were isolated from BALB/c mice. Cell viability, apoptosis and ROS production were evaluated in vitro. Cellular and suborgan biodisribution of the AuNPs were investigated using inductively coupled plasma mass spectrometry (ICP-MS) technique. PEI and PEG surface coating increased both biocom-patibility and biodistribution of the AuNPs. ICP-MS measurements showed the presence of gold in liver, spleen, kidney, heart, blood and brain within a 30 days period. The size and surface chemistry of the AuNPs are important parameters for potential nanoteranostic applications in the future studies.
dc.identifier.citationÖzçiçek, İ., Ayşit, N., Çakıcı, Ç. ve Aydeğer, A. (2021). The effects of surface functionality and size of gold nanoparticles on neuronal toxicity, apoptosis, ROS production and cellular/suborgan biodistribution. Materials Science and Engineering C, 128. https://dx.doi.org/10.1016/j.msec.2021.112308
dc.identifier.doi10.1016/j.msec.2021.112308
dc.identifier.issn0928-4931
dc.identifier.issn1873-0191
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://dx.doi.org/10.1016/j.msec.2021.112308
dc.identifier.urihttps://hdl.handle.net/20.500.12511/7679
dc.identifier.volume128
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier B.V.
dc.relation.ispartofMaterials Science and Engineering Cen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectBiodistribution
dc.subjectDRG Sensory Neuron
dc.subjectGold Nanoparticle
dc.subjectNanotoxicity
dc.subjectPEI/PEG Surface Functionalization
dc.titleThe effects of surface functionality and size of gold nanoparticles on neuronal toxicity, apoptosis, ROS production and cellular/suborgan biodistribution
dc.typeArticle

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