Abnormal cross frequency coupling of brain electroencephalographic oscillations related to visual oddball task in parkinson's disease with mild cognitive impairment

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dc.authorid0000-0001-5118-4776
dc.authorid0000-0002-7555-3801
dc.authorid0000-0003-4292-5717
dc.authorid0000-0002-7715-3035
dc.authorid0000-0002-0860-0524
dc.contributor.authorBayraktaroğlu, Zübeyir
dc.contributor.authorAktürk, Tuba
dc.contributor.authorYener, Görsev
dc.contributor.authorde Graaf, Tom A.
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorYıldırım, Ebru
dc.contributor.authorHünerli Gündüz, Duygu
dc.contributor.authorKıyı, İlayda
dc.contributor.authorSack, Alexander T.
dc.contributor.authorBabiloni, Claudio
dc.contributor.authorGüntekin, Bahar
dc.date.accessioned2023-09-26T08:02:15Z
dc.date.available2023-09-26T08:02:15Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Elektronörofizyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalı
dc.description.abstractParkinson's disease (PD) is a movement disorder caused by degeneration in dopaminergic neurons. During the disease course, most of PD patients develop mild cognitive impairment (PDMCI) and dementia, especially affecting frontal executive functions. In this study, we tested the hypothesis that PDMCI patients may be characterized by abnormal neurophysiological oscillatory mechanisms coupling frontal and posterior cortical areas during cognitive information processing. To test this hypothesis, event-related EEG oscillations (EROs) during counting visual target (rare) stimuli in an oddball task were recorded in healthy controls (HC; N = 51), cognitively unimpaired PD patients (N = 48), and PDMCI patients (N = 53). Hilbert transform served to estimate instantaneous phase and amplitude of EROs from delta to gamma frequency bands, while modulation index computed ERO phase-amplitude coupling (PAC) at electrode pairs. As compared to the HC and PD groups, the PDMCI group was characterized by (1) more posterior topography of the delta-theta PAC and (2) reversed delta-low frequency alpha PAC direction, ie, posterior-to-anterior rather than anterior-to-posterior. These results suggest that during cognitive demands, PDMCI patients are characterized by abnormal neurophysiological oscillatory mechanisms mainly led by delta frequencies underpinning functional connectivity from frontal to parietal cortical areas.
dc.identifier.citationBayraktaroğlu, Z., Aktürk, T., Yener, G., de Graaf, T. A., Hanoğlu, L., Yıldırım, E. ... Güntekin, B. (2023). Abnormal cross frequency coupling of brain electroencephalographic oscillations related to visual oddball task in parkinson's disease with mild cognitive impairment. Clinical EEG and Neuroscience, 54(4), 379-390. https://doi.org/10.1177/15500594221128713
dc.identifier.doi10.1177/15500594221128713
dc.identifier.endpage390
dc.identifier.issn1550-0594
dc.identifier.issn2169-5202
dc.identifier.issue4
dc.identifier.pmid36177504
dc.identifier.scopus2-s2.0-85139173707
dc.identifier.scopusqualityQ2
dc.identifier.startpage379
dc.identifier.urihttps://doi.org/10.1177/15500594221128713
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11497
dc.identifier.volume54
dc.identifier.wos000862082800001en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBayraktaroğlu, Zübeyir
dc.institutionauthorAktürk, Tuba
dc.institutionauthorHanoğlu, Lütfü
dc.institutionauthorYıldırım, Ebru
dc.institutionauthorGüntekin, Bahar
dc.language.isoen
dc.publisherSAGE Publications Inc.
dc.relation.ispartofClinical EEG and Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/214S111
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBrain Event-Related Oscillations (EROs)
dc.subjectCross-Frequency Coupling
dc.subjectOddball Paradigm
dc.subjectParkinson's Disease
dc.subjectParkinson's Disease With Mild Cognitive Impairment (PDMCI)
dc.titleAbnormal cross frequency coupling of brain electroencephalographic oscillations related to visual oddball task in parkinson's disease with mild cognitive impairment
dc.typeArticle

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