Physiological aspect of apoptosis-regulating microRNAs expressions during fasting

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dc.contributor.authorUlaş, Mustafa
dc.contributor.authorAkbaş, E.
dc.contributor.authorAkbaş, S.
dc.contributor.authorAktemur, Gizem
dc.contributor.authorDurcanoğlu, N.
dc.contributor.authorAksak, K.
dc.contributor.authorAtalar, Aslan Arda
dc.contributor.authorYıldırım, S.
dc.contributor.authorAkalın, I.
dc.date.accessioned2023-05-23T07:51:38Z
dc.date.available2023-05-23T07:51:38Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, Geleneksel ve Tamamlayıcı Tıp Ana Bilim Dalı
dc.description.abstractOBJECTIVE: Fasting is an activi-ty that requires a certain calorie restriction with-out consuming food or drinks for a certain pe-riod of daytime. However, fasting triggers ma-ny complex events, including activating cellular stress response pathways, autophagy promo-tion, apoptosis pathways, and a change in hor-monal balance. Among the many events affect-ing the regulation of apoptosis, the expression of microRNAs (miRNAs) plays an important role. Therefore, we aimed to investigate the levels and importance of miRNA expression in fasting.PATIENTS AND METHODS: The expressions of 19 miRNAs regulating different pathways from saliva samples, isolated by matching healthy university students (n = 34) as group 1 (fasting for 17 consecutive hours) and group 2 (testing 70 minutes after meal consumption), were exam-ined using the real-time PCR method. RESULTS: In fasting, modulation of apoptotic pathways by miRNAs triggers anti-pathogenic ef-fects, and the adaptation of abnormal cells in the body decreases. For this reason, vital diseases, such as cancer, can be treated by preventing the proliferation and growth of cancerous cells by in-creasing programmed cell death due to the down -regulation expression mechanism of miRNAs.CONCLUSIONS: Our study aims to improve the knowledge about the mechanisms and func-tions of miRNAs in various apoptosis pathways during fasting and may be a model for further fu-ture physiological and pathological studies.
dc.identifier.citationUlaş, M., Akbaş, E., Akbaş, S., Aktemur, G., Durcanoğlu, N., Aksak, K. ... Akalın, I. (2023). Physiological aspect of apoptosis-regulating microRNAs expressions during fasting. European Review for Medical and Pharmacological Sciences, 27(6), 2210-2215. https://doi.org/10.26355/eurrev_202303_31754
dc.identifier.doi10.26355/eurrev_202303_31754
dc.identifier.endpage2215
dc.identifier.issn1128-3602
dc.identifier.issue6
dc.identifier.pmid37013738
dc.identifier.scopus2-s2.0-85151749201
dc.identifier.scopusqualityQ2
dc.identifier.startpage2210
dc.identifier.urihttps://doi.org/10.26355/eurrev_202303_31754
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10952
dc.identifier.volume27
dc.identifier.wos000971936600004en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAkbaş, E.
dc.institutionauthorAkbaş, S.
dc.language.isoen
dc.publisherVerduci Publisher
dc.relation.ispartofEuropean Review for Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectMicroRNAs
dc.subjectFasting
dc.subjectPolymerase Chain Reaction
dc.subjectApoptotic Pathways
dc.subjectMiR/221-222
dc.titlePhysiological aspect of apoptosis-regulating microRNAs expressions during fasting
dc.typeArticle

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